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Sphingosine kinase 1 expression enhances colon tumor growth

BACKGROUND: Accumulating evidence suggests that sphingosine kinase 1 (SphK1)/sphingosine 1-phosphate pathway plays a pivotal role in colon carcinogenesis. METHODS: To further support the evidence, we investigated the effects of SphK1 using three separate animal models: SphK1 knockout mice, SphK1 ove...

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Detalles Bibliográficos
Autores principales:	Furuya, Hideki, Shimizu, Yoshiko, Tamashiro, Paulette M., Iino, Kayoko, Bielawski, Jacek, Chan, Owen T. M., Pagano, Ian, Kawamori, Toshihiko
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460497/ https://www.ncbi.nlm.nih.gov/pubmed/28583134 http://dx.doi.org/10.1186/s12967-017-1220-x

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