Cargando…

Antimicrobial susceptibility pattern of Shigella spp. isolated from children under 5 years of age attending tertiary care hospitals, Nepal along with first finding of ESBL-production

BACKGROUND: Shigella is an important cause of bacterial gastroenteritis in resource-poor countries. The treatment of shigellosis mostly requires antibiotics. However, the increase of multidrug resistance along with emergence of extended-spectrum β-lactamase and ciprofloxacin resistance among Shigell...

Descripción completa

Detalles Bibliográficos
Autores principales: Dhital, Subhash, Sherchand, Jeevan Bahadur, Pokharel, Bharat Mani, Parajuli, Keshab, Mishra, Shyam Kumar, Sharma, Sangita, Kattel, Hari Prasad, Khadka, Sundar, Khatiwada, Sulochana, Rijal, Basista
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460519/
https://www.ncbi.nlm.nih.gov/pubmed/28583187
http://dx.doi.org/10.1186/s13104-017-2512-1
_version_ 1783242194535055360
author Dhital, Subhash
Sherchand, Jeevan Bahadur
Pokharel, Bharat Mani
Parajuli, Keshab
Mishra, Shyam Kumar
Sharma, Sangita
Kattel, Hari Prasad
Khadka, Sundar
Khatiwada, Sulochana
Rijal, Basista
author_facet Dhital, Subhash
Sherchand, Jeevan Bahadur
Pokharel, Bharat Mani
Parajuli, Keshab
Mishra, Shyam Kumar
Sharma, Sangita
Kattel, Hari Prasad
Khadka, Sundar
Khatiwada, Sulochana
Rijal, Basista
author_sort Dhital, Subhash
collection PubMed
description BACKGROUND: Shigella is an important cause of bacterial gastroenteritis in resource-poor countries. The treatment of shigellosis mostly requires antibiotics. However, the increase of multidrug resistance along with emergence of extended-spectrum β-lactamase and ciprofloxacin resistance among Shigella spp. has challenged the situation. This study was conducted to determine the distribution of species and antibiotic susceptibility pattern of Shigella species isolated from stool specimen among children less than 5 years of age in Nepal. RESULTS: Out of total 717 stool samples collected, 15 cases of Shigella spp. was isolated which includes 12 S. flexneri and 3 S. sonnei. Multidrug resistance was found among 13(86%) of the isolates. One of the isolates of S. flexneri was found to be ESBL-producer with MIC >256 mg/L for cefixime. CONCLUSION: The high occurrence of multidrug resistance among Shigella spp. along with a case of ESBL-production for the first time in Nepal alarms the concerns about dissemination of the resistant isolates. So, systemic monitoring of the antimicrobial susceptibility pattern of Shigella spp. is becoming crucial to guide therapy.
format Online
Article
Text
id pubmed-5460519
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-54605192017-06-07 Antimicrobial susceptibility pattern of Shigella spp. isolated from children under 5 years of age attending tertiary care hospitals, Nepal along with first finding of ESBL-production Dhital, Subhash Sherchand, Jeevan Bahadur Pokharel, Bharat Mani Parajuli, Keshab Mishra, Shyam Kumar Sharma, Sangita Kattel, Hari Prasad Khadka, Sundar Khatiwada, Sulochana Rijal, Basista BMC Res Notes Short Report BACKGROUND: Shigella is an important cause of bacterial gastroenteritis in resource-poor countries. The treatment of shigellosis mostly requires antibiotics. However, the increase of multidrug resistance along with emergence of extended-spectrum β-lactamase and ciprofloxacin resistance among Shigella spp. has challenged the situation. This study was conducted to determine the distribution of species and antibiotic susceptibility pattern of Shigella species isolated from stool specimen among children less than 5 years of age in Nepal. RESULTS: Out of total 717 stool samples collected, 15 cases of Shigella spp. was isolated which includes 12 S. flexneri and 3 S. sonnei. Multidrug resistance was found among 13(86%) of the isolates. One of the isolates of S. flexneri was found to be ESBL-producer with MIC >256 mg/L for cefixime. CONCLUSION: The high occurrence of multidrug resistance among Shigella spp. along with a case of ESBL-production for the first time in Nepal alarms the concerns about dissemination of the resistant isolates. So, systemic monitoring of the antimicrobial susceptibility pattern of Shigella spp. is becoming crucial to guide therapy. BioMed Central 2017-06-05 /pmc/articles/PMC5460519/ /pubmed/28583187 http://dx.doi.org/10.1186/s13104-017-2512-1 Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Short Report
Dhital, Subhash
Sherchand, Jeevan Bahadur
Pokharel, Bharat Mani
Parajuli, Keshab
Mishra, Shyam Kumar
Sharma, Sangita
Kattel, Hari Prasad
Khadka, Sundar
Khatiwada, Sulochana
Rijal, Basista
Antimicrobial susceptibility pattern of Shigella spp. isolated from children under 5 years of age attending tertiary care hospitals, Nepal along with first finding of ESBL-production
title Antimicrobial susceptibility pattern of Shigella spp. isolated from children under 5 years of age attending tertiary care hospitals, Nepal along with first finding of ESBL-production
title_full Antimicrobial susceptibility pattern of Shigella spp. isolated from children under 5 years of age attending tertiary care hospitals, Nepal along with first finding of ESBL-production
title_fullStr Antimicrobial susceptibility pattern of Shigella spp. isolated from children under 5 years of age attending tertiary care hospitals, Nepal along with first finding of ESBL-production
title_full_unstemmed Antimicrobial susceptibility pattern of Shigella spp. isolated from children under 5 years of age attending tertiary care hospitals, Nepal along with first finding of ESBL-production
title_short Antimicrobial susceptibility pattern of Shigella spp. isolated from children under 5 years of age attending tertiary care hospitals, Nepal along with first finding of ESBL-production
title_sort antimicrobial susceptibility pattern of shigella spp. isolated from children under 5 years of age attending tertiary care hospitals, nepal along with first finding of esbl-production
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460519/
https://www.ncbi.nlm.nih.gov/pubmed/28583187
http://dx.doi.org/10.1186/s13104-017-2512-1
work_keys_str_mv AT dhitalsubhash antimicrobialsusceptibilitypatternofshigellasppisolatedfromchildrenunder5yearsofageattendingtertiarycarehospitalsnepalalongwithfirstfindingofesblproduction
AT sherchandjeevanbahadur antimicrobialsusceptibilitypatternofshigellasppisolatedfromchildrenunder5yearsofageattendingtertiarycarehospitalsnepalalongwithfirstfindingofesblproduction
AT pokharelbharatmani antimicrobialsusceptibilitypatternofshigellasppisolatedfromchildrenunder5yearsofageattendingtertiarycarehospitalsnepalalongwithfirstfindingofesblproduction
AT parajulikeshab antimicrobialsusceptibilitypatternofshigellasppisolatedfromchildrenunder5yearsofageattendingtertiarycarehospitalsnepalalongwithfirstfindingofesblproduction
AT mishrashyamkumar antimicrobialsusceptibilitypatternofshigellasppisolatedfromchildrenunder5yearsofageattendingtertiarycarehospitalsnepalalongwithfirstfindingofesblproduction
AT sharmasangita antimicrobialsusceptibilitypatternofshigellasppisolatedfromchildrenunder5yearsofageattendingtertiarycarehospitalsnepalalongwithfirstfindingofesblproduction
AT kattelhariprasad antimicrobialsusceptibilitypatternofshigellasppisolatedfromchildrenunder5yearsofageattendingtertiarycarehospitalsnepalalongwithfirstfindingofesblproduction
AT khadkasundar antimicrobialsusceptibilitypatternofshigellasppisolatedfromchildrenunder5yearsofageattendingtertiarycarehospitalsnepalalongwithfirstfindingofesblproduction
AT khatiwadasulochana antimicrobialsusceptibilitypatternofshigellasppisolatedfromchildrenunder5yearsofageattendingtertiarycarehospitalsnepalalongwithfirstfindingofesblproduction
AT rijalbasista antimicrobialsusceptibilitypatternofshigellasppisolatedfromchildrenunder5yearsofageattendingtertiarycarehospitalsnepalalongwithfirstfindingofesblproduction