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Antimicrobial susceptibility pattern of Shigella spp. isolated from children under 5 years of age attending tertiary care hospitals, Nepal along with first finding of ESBL-production
BACKGROUND: Shigella is an important cause of bacterial gastroenteritis in resource-poor countries. The treatment of shigellosis mostly requires antibiotics. However, the increase of multidrug resistance along with emergence of extended-spectrum β-lactamase and ciprofloxacin resistance among Shigell...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460519/ https://www.ncbi.nlm.nih.gov/pubmed/28583187 http://dx.doi.org/10.1186/s13104-017-2512-1 |
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author | Dhital, Subhash Sherchand, Jeevan Bahadur Pokharel, Bharat Mani Parajuli, Keshab Mishra, Shyam Kumar Sharma, Sangita Kattel, Hari Prasad Khadka, Sundar Khatiwada, Sulochana Rijal, Basista |
author_facet | Dhital, Subhash Sherchand, Jeevan Bahadur Pokharel, Bharat Mani Parajuli, Keshab Mishra, Shyam Kumar Sharma, Sangita Kattel, Hari Prasad Khadka, Sundar Khatiwada, Sulochana Rijal, Basista |
author_sort | Dhital, Subhash |
collection | PubMed |
description | BACKGROUND: Shigella is an important cause of bacterial gastroenteritis in resource-poor countries. The treatment of shigellosis mostly requires antibiotics. However, the increase of multidrug resistance along with emergence of extended-spectrum β-lactamase and ciprofloxacin resistance among Shigella spp. has challenged the situation. This study was conducted to determine the distribution of species and antibiotic susceptibility pattern of Shigella species isolated from stool specimen among children less than 5 years of age in Nepal. RESULTS: Out of total 717 stool samples collected, 15 cases of Shigella spp. was isolated which includes 12 S. flexneri and 3 S. sonnei. Multidrug resistance was found among 13(86%) of the isolates. One of the isolates of S. flexneri was found to be ESBL-producer with MIC >256 mg/L for cefixime. CONCLUSION: The high occurrence of multidrug resistance among Shigella spp. along with a case of ESBL-production for the first time in Nepal alarms the concerns about dissemination of the resistant isolates. So, systemic monitoring of the antimicrobial susceptibility pattern of Shigella spp. is becoming crucial to guide therapy. |
format | Online Article Text |
id | pubmed-5460519 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-54605192017-06-07 Antimicrobial susceptibility pattern of Shigella spp. isolated from children under 5 years of age attending tertiary care hospitals, Nepal along with first finding of ESBL-production Dhital, Subhash Sherchand, Jeevan Bahadur Pokharel, Bharat Mani Parajuli, Keshab Mishra, Shyam Kumar Sharma, Sangita Kattel, Hari Prasad Khadka, Sundar Khatiwada, Sulochana Rijal, Basista BMC Res Notes Short Report BACKGROUND: Shigella is an important cause of bacterial gastroenteritis in resource-poor countries. The treatment of shigellosis mostly requires antibiotics. However, the increase of multidrug resistance along with emergence of extended-spectrum β-lactamase and ciprofloxacin resistance among Shigella spp. has challenged the situation. This study was conducted to determine the distribution of species and antibiotic susceptibility pattern of Shigella species isolated from stool specimen among children less than 5 years of age in Nepal. RESULTS: Out of total 717 stool samples collected, 15 cases of Shigella spp. was isolated which includes 12 S. flexneri and 3 S. sonnei. Multidrug resistance was found among 13(86%) of the isolates. One of the isolates of S. flexneri was found to be ESBL-producer with MIC >256 mg/L for cefixime. CONCLUSION: The high occurrence of multidrug resistance among Shigella spp. along with a case of ESBL-production for the first time in Nepal alarms the concerns about dissemination of the resistant isolates. So, systemic monitoring of the antimicrobial susceptibility pattern of Shigella spp. is becoming crucial to guide therapy. BioMed Central 2017-06-05 /pmc/articles/PMC5460519/ /pubmed/28583187 http://dx.doi.org/10.1186/s13104-017-2512-1 Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Short Report Dhital, Subhash Sherchand, Jeevan Bahadur Pokharel, Bharat Mani Parajuli, Keshab Mishra, Shyam Kumar Sharma, Sangita Kattel, Hari Prasad Khadka, Sundar Khatiwada, Sulochana Rijal, Basista Antimicrobial susceptibility pattern of Shigella spp. isolated from children under 5 years of age attending tertiary care hospitals, Nepal along with first finding of ESBL-production |
title | Antimicrobial susceptibility pattern of Shigella spp. isolated from children under 5 years of age attending tertiary care hospitals, Nepal along with first finding of ESBL-production |
title_full | Antimicrobial susceptibility pattern of Shigella spp. isolated from children under 5 years of age attending tertiary care hospitals, Nepal along with first finding of ESBL-production |
title_fullStr | Antimicrobial susceptibility pattern of Shigella spp. isolated from children under 5 years of age attending tertiary care hospitals, Nepal along with first finding of ESBL-production |
title_full_unstemmed | Antimicrobial susceptibility pattern of Shigella spp. isolated from children under 5 years of age attending tertiary care hospitals, Nepal along with first finding of ESBL-production |
title_short | Antimicrobial susceptibility pattern of Shigella spp. isolated from children under 5 years of age attending tertiary care hospitals, Nepal along with first finding of ESBL-production |
title_sort | antimicrobial susceptibility pattern of shigella spp. isolated from children under 5 years of age attending tertiary care hospitals, nepal along with first finding of esbl-production |
topic | Short Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460519/ https://www.ncbi.nlm.nih.gov/pubmed/28583187 http://dx.doi.org/10.1186/s13104-017-2512-1 |
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