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Patterns in antimicrobial susceptibility of Salmonellae isolated at a tertiary care hospital in northern India

BACKGROUND & OBJECTIVES: Multidrug-resistant Salmonellae have emerged worldwide as also in India. The aim of this study was to study the antimicrobial susceptibility pattern of Salmonella enterica serovars isolated at a tertiary care hospital in northern India. METHODS: A total of 106 S. enteric...

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Autores principales: Behl, Preeti, Gupta, Varsha, Sachdev, Atul, Guglani, Vishal, Chander, Jagdish
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460558/
https://www.ncbi.nlm.nih.gov/pubmed/28574025
http://dx.doi.org/10.4103/ijmr.IJMR_862_14
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author Behl, Preeti
Gupta, Varsha
Sachdev, Atul
Guglani, Vishal
Chander, Jagdish
author_facet Behl, Preeti
Gupta, Varsha
Sachdev, Atul
Guglani, Vishal
Chander, Jagdish
author_sort Behl, Preeti
collection PubMed
description BACKGROUND & OBJECTIVES: Multidrug-resistant Salmonellae have emerged worldwide as also in India. The aim of this study was to study the antimicrobial susceptibility pattern of Salmonella enterica serovars isolated at a tertiary care hospital in northern India. METHODS: A total of 106 S. enterica serovars isolated from various clinical samples from January 2011 to June 2012 were tested for antimicrobial susceptibility by Kirby-Bauer disk diffusion method. The minimum inhibitory concentration (MIC) of ciprofloxacin, chloramphenicol and ceftriaxone was determined both by agar dilution method and E-test for all the isolates. RESULTS: Salmonella Typhi (73.6%) was the predominant isolate followed by S. Paratyphi A (15.1%), S. Typhimurium (9.4%) and S. Enteritidis (1.9%). Of these, 34 (32.1%) were resistant to ciprofloxacin (MIC ≥1 μg/ml by agar dilution) with MIC(90) of ciprofloxacin for S. Typhi, S. Paratyphi A and S. Typhimurium being 32, 4 and 1 μg/ml, respectively. All the isolates were sensitive to chloramphenicol (MIC ≤8 μg/ml) and ceftriaxone (MIC ≤1 μg/ml). Disk diffusion method showed high susceptibility rates to cefotaxime (100%), azithromycin (93.4%) and co-trimoxazole (97.2%). Nalidixic acid resistance was seen in 105 (99.1%) isolates. Of the nalidixic acid-resistant strains, only 34 (32.3%) were found to be resistant to ciprofloxacin (MIC ≥1 μg/ml). INTERPRETATION & CONCLUSIONS: This study showed an alarming increase in MIC to quinolones and re-emergence of susceptibility to conventional antibiotics among Salmonellae.
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spelling pubmed-54605582017-06-12 Patterns in antimicrobial susceptibility of Salmonellae isolated at a tertiary care hospital in northern India Behl, Preeti Gupta, Varsha Sachdev, Atul Guglani, Vishal Chander, Jagdish Indian J Med Res Original Article BACKGROUND & OBJECTIVES: Multidrug-resistant Salmonellae have emerged worldwide as also in India. The aim of this study was to study the antimicrobial susceptibility pattern of Salmonella enterica serovars isolated at a tertiary care hospital in northern India. METHODS: A total of 106 S. enterica serovars isolated from various clinical samples from January 2011 to June 2012 were tested for antimicrobial susceptibility by Kirby-Bauer disk diffusion method. The minimum inhibitory concentration (MIC) of ciprofloxacin, chloramphenicol and ceftriaxone was determined both by agar dilution method and E-test for all the isolates. RESULTS: Salmonella Typhi (73.6%) was the predominant isolate followed by S. Paratyphi A (15.1%), S. Typhimurium (9.4%) and S. Enteritidis (1.9%). Of these, 34 (32.1%) were resistant to ciprofloxacin (MIC ≥1 μg/ml by agar dilution) with MIC(90) of ciprofloxacin for S. Typhi, S. Paratyphi A and S. Typhimurium being 32, 4 and 1 μg/ml, respectively. All the isolates were sensitive to chloramphenicol (MIC ≤8 μg/ml) and ceftriaxone (MIC ≤1 μg/ml). Disk diffusion method showed high susceptibility rates to cefotaxime (100%), azithromycin (93.4%) and co-trimoxazole (97.2%). Nalidixic acid resistance was seen in 105 (99.1%) isolates. Of the nalidixic acid-resistant strains, only 34 (32.3%) were found to be resistant to ciprofloxacin (MIC ≥1 μg/ml). INTERPRETATION & CONCLUSIONS: This study showed an alarming increase in MIC to quinolones and re-emergence of susceptibility to conventional antibiotics among Salmonellae. Medknow Publications & Media Pvt Ltd 2017-01 /pmc/articles/PMC5460558/ /pubmed/28574025 http://dx.doi.org/10.4103/ijmr.IJMR_862_14 Text en Copyright: © 2017 Indian Journal of Medical Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Original Article
Behl, Preeti
Gupta, Varsha
Sachdev, Atul
Guglani, Vishal
Chander, Jagdish
Patterns in antimicrobial susceptibility of Salmonellae isolated at a tertiary care hospital in northern India
title Patterns in antimicrobial susceptibility of Salmonellae isolated at a tertiary care hospital in northern India
title_full Patterns in antimicrobial susceptibility of Salmonellae isolated at a tertiary care hospital in northern India
title_fullStr Patterns in antimicrobial susceptibility of Salmonellae isolated at a tertiary care hospital in northern India
title_full_unstemmed Patterns in antimicrobial susceptibility of Salmonellae isolated at a tertiary care hospital in northern India
title_short Patterns in antimicrobial susceptibility of Salmonellae isolated at a tertiary care hospital in northern India
title_sort patterns in antimicrobial susceptibility of salmonellae isolated at a tertiary care hospital in northern india
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460558/
https://www.ncbi.nlm.nih.gov/pubmed/28574025
http://dx.doi.org/10.4103/ijmr.IJMR_862_14
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