Cargando…
Potential biomarkers for bipolar disorder: Where do we stand?
Bipolar disorder (BD) is a severe, recurrent mood disorder, associated with a significant morbidity and mortality, with high rates of suicides and medical comorbidities. There is a high risk of mood disorders among the first-degree relatives of patients with BD. In the current clinical practice, the...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460576/ https://www.ncbi.nlm.nih.gov/pubmed/28574009 http://dx.doi.org/10.4103/ijmr.IJMR_1386_16 |
_version_ | 1783242207241699328 |
---|---|
author | Sagar, Rajesh Pattanayak, Raman Deep |
author_facet | Sagar, Rajesh Pattanayak, Raman Deep |
author_sort | Sagar, Rajesh |
collection | PubMed |
description | Bipolar disorder (BD) is a severe, recurrent mood disorder, associated with a significant morbidity and mortality, with high rates of suicides and medical comorbidities. There is a high risk of mood disorders among the first-degree relatives of patients with BD. In the current clinical practice, the diagnosis of BD is made by history taking, interview and behavioural observations, thereby lacking an objective, biological validation. This approach may result in underdiagnosis, misdiagnosis and eventually poorer outcomes. Due to the heterogeneity of BD, the possibility of developing a single, specific biomarker is still remote; however, there is a set of promising biomarkers which may serve as predictive, prognostic or treatment markers in the future. The review presents a critical appraisal and update on some of the most promising candidates for biomarkers, namely, neuroimaging markers, peripheral biomarkers and genetic markers, including a brief discussion on cognitive endophenotypes as indicative of genetic risk. The lessons learnt from other fields and specialties in medicine need to be applied to psychiatry to translate the knowledge from ‘bench to bedside’ by means of clinically useful biomarkers. Overall, the biomarkers may help in pushing the shift towards personalized medicine for psychiatric patients. |
format | Online Article Text |
id | pubmed-5460576 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-54605762017-06-12 Potential biomarkers for bipolar disorder: Where do we stand? Sagar, Rajesh Pattanayak, Raman Deep Indian J Med Res Review Article Bipolar disorder (BD) is a severe, recurrent mood disorder, associated with a significant morbidity and mortality, with high rates of suicides and medical comorbidities. There is a high risk of mood disorders among the first-degree relatives of patients with BD. In the current clinical practice, the diagnosis of BD is made by history taking, interview and behavioural observations, thereby lacking an objective, biological validation. This approach may result in underdiagnosis, misdiagnosis and eventually poorer outcomes. Due to the heterogeneity of BD, the possibility of developing a single, specific biomarker is still remote; however, there is a set of promising biomarkers which may serve as predictive, prognostic or treatment markers in the future. The review presents a critical appraisal and update on some of the most promising candidates for biomarkers, namely, neuroimaging markers, peripheral biomarkers and genetic markers, including a brief discussion on cognitive endophenotypes as indicative of genetic risk. The lessons learnt from other fields and specialties in medicine need to be applied to psychiatry to translate the knowledge from ‘bench to bedside’ by means of clinically useful biomarkers. Overall, the biomarkers may help in pushing the shift towards personalized medicine for psychiatric patients. Medknow Publications & Media Pvt Ltd 2017-01 /pmc/articles/PMC5460576/ /pubmed/28574009 http://dx.doi.org/10.4103/ijmr.IJMR_1386_16 Text en Copyright: © 2017 Indian Journal of Medical Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Review Article Sagar, Rajesh Pattanayak, Raman Deep Potential biomarkers for bipolar disorder: Where do we stand? |
title | Potential biomarkers for bipolar disorder: Where do we stand? |
title_full | Potential biomarkers for bipolar disorder: Where do we stand? |
title_fullStr | Potential biomarkers for bipolar disorder: Where do we stand? |
title_full_unstemmed | Potential biomarkers for bipolar disorder: Where do we stand? |
title_short | Potential biomarkers for bipolar disorder: Where do we stand? |
title_sort | potential biomarkers for bipolar disorder: where do we stand? |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460576/ https://www.ncbi.nlm.nih.gov/pubmed/28574009 http://dx.doi.org/10.4103/ijmr.IJMR_1386_16 |
work_keys_str_mv | AT sagarrajesh potentialbiomarkersforbipolardisorderwheredowestand AT pattanayakramandeep potentialbiomarkersforbipolardisorderwheredowestand |