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Parental alcohol use and risk of behavioral and emotional problems in offspring

OBJECTIVE: The majority of studies that have examined parental alcohol use and offspring outcomes have either focused on exposure in the antenatal period or from clinical populations. This study sought to examine proximal and distal associations between parental alcohol use and offspring conduct pro...

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Autores principales: Mahedy, Liam, Hammerton, Gemma, Teyhan, Alison, Edwards, Alexis C., Kendler, Kenneth S., Moore, Simon C., Hickman, Matthew, Macleod, John, Heron, Jon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460848/
https://www.ncbi.nlm.nih.gov/pubmed/28586358
http://dx.doi.org/10.1371/journal.pone.0178862
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author Mahedy, Liam
Hammerton, Gemma
Teyhan, Alison
Edwards, Alexis C.
Kendler, Kenneth S.
Moore, Simon C.
Hickman, Matthew
Macleod, John
Heron, Jon
author_facet Mahedy, Liam
Hammerton, Gemma
Teyhan, Alison
Edwards, Alexis C.
Kendler, Kenneth S.
Moore, Simon C.
Hickman, Matthew
Macleod, John
Heron, Jon
author_sort Mahedy, Liam
collection PubMed
description OBJECTIVE: The majority of studies that have examined parental alcohol use and offspring outcomes have either focused on exposure in the antenatal period or from clinical populations. This study sought to examine proximal and distal associations between parental alcohol use and offspring conduct problems and depressive symptoms in a population birth cohort. METHODS: We used prospective data from a large UK based population cohort (ALSPAC) to investigate the association between parental alcohol use, measured in units, (assessed at ages 4 and 12 years) with childhood conduct trajectories, (assessed on six occasions from 4 to 13.5 years, n = 6,927), and adolescent depressive symptoms (assessed on four occasions from ~13 to ~18 years, n = 5,539). Heavy drinking was defined as ≥21 units per week in mothers and partners who drank 4+ units daily. RESULTS: We found little evidence to support a dose response association between parental alcohol use and offspring outcomes. For example, we found insufficient evidence to support an association between maternal alcohol use at age 4 years and childhood conduct problems (childhood limited: OR = 1.00, 95% CI = .99, 1.01; adolescent onset: OR = 0.99, 95% CI = .98, 1.00; and early-onset persistent: OR = 0.99, 95% CI = .98, 1.00) per 1-unit change in maternal alcohol use compared to those with low levels of conduct problems. We also found insufficient evidence to support an association between maternal alcohol use at age 4 years and adolescent depressive symptoms (intercept: b = .001, 95% CI = -.01, .01, and slope: b = .003, 95% CI = -.03, .03) per 1-unit change in maternal alcohol use. Results remained consistent across amount of alcohol consumed (i.e., number of alcohol units or heavy alcohol use), parent (maternal self-reports or maternal reports of partner’s alcohol use), and timing of alcohol use (assessed at age 4 or age 12 years). CONCLUSIONS: There is no support for an association between parental alcohol use during childhood and conduct and emotional problems during childhood or adolescence.
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spelling pubmed-54608482017-06-15 Parental alcohol use and risk of behavioral and emotional problems in offspring Mahedy, Liam Hammerton, Gemma Teyhan, Alison Edwards, Alexis C. Kendler, Kenneth S. Moore, Simon C. Hickman, Matthew Macleod, John Heron, Jon PLoS One Research Article OBJECTIVE: The majority of studies that have examined parental alcohol use and offspring outcomes have either focused on exposure in the antenatal period or from clinical populations. This study sought to examine proximal and distal associations between parental alcohol use and offspring conduct problems and depressive symptoms in a population birth cohort. METHODS: We used prospective data from a large UK based population cohort (ALSPAC) to investigate the association between parental alcohol use, measured in units, (assessed at ages 4 and 12 years) with childhood conduct trajectories, (assessed on six occasions from 4 to 13.5 years, n = 6,927), and adolescent depressive symptoms (assessed on four occasions from ~13 to ~18 years, n = 5,539). Heavy drinking was defined as ≥21 units per week in mothers and partners who drank 4+ units daily. RESULTS: We found little evidence to support a dose response association between parental alcohol use and offspring outcomes. For example, we found insufficient evidence to support an association between maternal alcohol use at age 4 years and childhood conduct problems (childhood limited: OR = 1.00, 95% CI = .99, 1.01; adolescent onset: OR = 0.99, 95% CI = .98, 1.00; and early-onset persistent: OR = 0.99, 95% CI = .98, 1.00) per 1-unit change in maternal alcohol use compared to those with low levels of conduct problems. We also found insufficient evidence to support an association between maternal alcohol use at age 4 years and adolescent depressive symptoms (intercept: b = .001, 95% CI = -.01, .01, and slope: b = .003, 95% CI = -.03, .03) per 1-unit change in maternal alcohol use. Results remained consistent across amount of alcohol consumed (i.e., number of alcohol units or heavy alcohol use), parent (maternal self-reports or maternal reports of partner’s alcohol use), and timing of alcohol use (assessed at age 4 or age 12 years). CONCLUSIONS: There is no support for an association between parental alcohol use during childhood and conduct and emotional problems during childhood or adolescence. Public Library of Science 2017-06-06 /pmc/articles/PMC5460848/ /pubmed/28586358 http://dx.doi.org/10.1371/journal.pone.0178862 Text en © 2017 Mahedy et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Mahedy, Liam
Hammerton, Gemma
Teyhan, Alison
Edwards, Alexis C.
Kendler, Kenneth S.
Moore, Simon C.
Hickman, Matthew
Macleod, John
Heron, Jon
Parental alcohol use and risk of behavioral and emotional problems in offspring
title Parental alcohol use and risk of behavioral and emotional problems in offspring
title_full Parental alcohol use and risk of behavioral and emotional problems in offspring
title_fullStr Parental alcohol use and risk of behavioral and emotional problems in offspring
title_full_unstemmed Parental alcohol use and risk of behavioral and emotional problems in offspring
title_short Parental alcohol use and risk of behavioral and emotional problems in offspring
title_sort parental alcohol use and risk of behavioral and emotional problems in offspring
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460848/
https://www.ncbi.nlm.nih.gov/pubmed/28586358
http://dx.doi.org/10.1371/journal.pone.0178862
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