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Overexpression of the essential Sis1 chaperone reduces TDP-43 effects on toxicity and proteolysis

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by selective loss of motor neurons with inclusions frequently containing the RNA/DNA binding protein TDP-43. Using a yeast model of ALS exhibiting TDP-43 dependent toxicity, we now show that TDP-43 overexpre...

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Detalles Bibliográficos
Autores principales:	Park, Sei-Kyoung, Hong, Joo Y., Arslan, Fatih, Kanneganti, Vydehi, Patel, Basant, Tietsort, Alex, Tank, Elizabeth M. H., Li, Xingli, Barmada, Sami J., Liebman, Susan W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460882/ https://www.ncbi.nlm.nih.gov/pubmed/28531192 http://dx.doi.org/10.1371/journal.pgen.1006805

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