Impact of mutations in Toll-like receptor pathway genes on esophageal carcinogenesis

Esophageal adenocarcinoma (EAC) develops in an inflammatory microenvironment with reduced microbial diversity, but mechanisms for these influences remain poorly characterized. We hypothesized that mutations targeting the Toll-like receptor (TLR) pathway could disrupt innate immune signaling and prom...

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Detalles Bibliográficos
Autores principales: Fels Elliott, Daffolyn Rachael, Perner, Juliane, Li, Xiaodun, Symmons, Martyn F., Verstak, Brett, Eldridge, Matthew, Bower, Lawrence, O’Donovan, Maria, Gay, Nick J., Fitzgerald, Rebecca C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460900/
https://www.ncbi.nlm.nih.gov/pubmed/28531216
http://dx.doi.org/10.1371/journal.pgen.1006808

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