Integrin-targeted cancer immunotherapy elicits protective adaptive immune responses

Certain RGD-binding integrins are required for cell adhesion, migration, and proliferation and are overexpressed in most tumors, making them attractive therapeutic targets. However, multiple integrin antagonist drug candidates have failed to show efficacy in cancer clinical trials. In this work, we...

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Detalles Bibliográficos
Autores principales: Kwan, Byron H., Zhu, Eric F., Tzeng, Alice, Sugito, Harun R., Eltahir, Ahmed A., Ma, Botong, Delaney, Mary K., Murphy, Patrick A., Kauke, Monique J., Angelini, Alessandro, Momin, Noor, Mehta, Naveen K., Maragh, Alecia M., Hynes, Richard O., Dranoff, Glenn, Cochran, Jennifer R., Wittrup, K. Dane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460993/
https://www.ncbi.nlm.nih.gov/pubmed/28473400
http://dx.doi.org/10.1084/jem.20160831

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460993/
https://www.ncbi.nlm.nih.gov/pubmed/28473400
http://dx.doi.org/10.1084/jem.20160831

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