Cargando…

Integrin-targeted cancer immunotherapy elicits protective adaptive immune responses

Certain RGD-binding integrins are required for cell adhesion, migration, and proliferation and are overexpressed in most tumors, making them attractive therapeutic targets. However, multiple integrin antagonist drug candidates have failed to show efficacy in cancer clinical trials. In this work, we...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kwan, Byron H., Zhu, Eric F., Tzeng, Alice, Sugito, Harun R., Eltahir, Ahmed A., Ma, Botong, Delaney, Mary K., Murphy, Patrick A., Kauke, Monique J., Angelini, Alessandro, Momin, Noor, Mehta, Naveen K., Maragh, Alecia M., Hynes, Richard O., Dranoff, Glenn, Cochran, Jennifer R., Wittrup, K. Dane
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2017
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460993/ https://www.ncbi.nlm.nih.gov/pubmed/28473400 http://dx.doi.org/10.1084/jem.20160831

Ejemplares similares

Intratumoral nanobody–IL-2 fusions that bind the tumor extracellular matrix suppress solid tumor growth in mice
por: Lutz, Emi A, et al.
Publicado: (2022)

Chaperone proteins as single component reagents to assess antibody nonspecificity
por: Kelly, Ryan L., et al.
Publicado: (2017)

Maximizing response to intratumoral immunotherapy in mice by tuning local retention
por: Momin, Noor, et al.
Publicado: (2022)

Immunotherapy-induced antibodies to endogenous retroviral envelope glycoprotein confer tumor protection in mice
por: Kang, Byong H., et al.
Publicado: (2021)

An engineered protein antagonist of K-Ras/B-Raf interaction
por: Kauke, Monique J., et al.
Publicado: (2017)

Cytosolic delivery of siRNA by ultra-high affinity dsRNA binding proteins
por: Yang, Nicole J., et al.
Publicado: (2017)

Combining the Specific Anti-MUC1 Antibody TAB004 and Lip-MSA-IL-2 Limits Pancreatic Cancer Progression in Immune Competent Murine Models of Pancreatic Ductal Adenocarcinoma
por: Dréau, Didier, et al.
Publicado: (2019)

Yeast surface display for protein engineering and characterization
por: Gai, S Annie, et al.
Publicado: (2007)

Directed evolution of broadly crossreactive chemokine-blocking antibodies efficacious in arthritis
por: Angelini, Alessandro, et al.
Publicado: (2018)

Combined treatment using adoptive cell therapy, extended pharmacokinetic IL-2, and tumor-specific antibodies leads to cures of established B16F10 tumors and extended in vivo T cell survival
por: Opel, Cary F, et al.
Publicado: (2013)

Co‐Anchoring of Engineered Immunogen and Immunostimulatory Cytokines to Alum Promotes Enhanced‐Humoral Immunity
por: Chang, Jason Y. H., et al.
Publicado: (2022)

Engineered gp120 immunogens that elicit VRC01-like antibodies by vaccination
por: Mata-Fink, J, et al.
Publicado: (2012)

A Nonpolycationic Fully Proteinaceous Multiagent System for Potent Targeted Delivery of siRNA
por: Liu, David V, et al.
Publicado: (2014)

Synergistic Antitumor Activity from Two-Stage Delivery of Targeted Toxins and Endosome-Disrupting Nanoparticles
por: Su, Xingfang, et al.
Publicado: (2013)

Nonspecificity in a nonimmune human scFv repertoire
por: Kelly, Ryan L., et al.
Publicado: (2017)

Intratumourally injected alum-tethered cytokines elicit potent and safer local and systemic anticancer immunity
por: Agarwal, Yash, et al.
Publicado: (2022)

Overcoming lung cancer immunotherapy resistance by combining nontoxic variants of IL-12 and IL-2
por: Horton, Brendan L., et al.
Publicado: (2023)

Alum-anchored intratumoral retention improves the tolerability and antitumor efficacy of type I interferon therapies
por: Lutz, Emi A., et al.
Publicado: (2022)

Cucurbitacins Elicit Anti-Platelet Activity via Perturbation of the Cytoskeleton and Integrin Function
por: Kriek, Neline, et al.
Publicado: (2022)

Strong Enrichment of Aromatic Residues in Binding Sites from a Charge-neutralized Hyperthermostable Sso7d Scaffold Library
por: Traxlmayr, Michael W., et al.
Publicado: (2016)

Tumor Angiogenesis in the Absence of Fibronectin or Its Cognate Integrin Receptors
por: Murphy, Patrick A., et al.
Publicado: (2015)

α4β1 integrin and erythropoietin mediate temporally distinct steps in erythropoiesis: integrins in red cell development
por: Eshghi, Shawdee, et al.
Publicado: (2008)

α(4)β(1) integrin and erythropoietin mediate temporally distinct steps in erythropoiesis: integrins in red cell development
por: Eshghi, Shawdee, et al.
Publicado: (2007)

Expression of the 180-Kd Ribosome Receptor Induces Membrane Proliferation and Increased Secretory Activity in Yeast
por: Becker, Frank, et al.
Publicado: (1999)

Connecting the sequence dots: shedding light on the genesis of antibodies reported to be designed in silico
por: Vásquez, Maximiliano, et al.
Publicado: (2019)

Integrin-mediated Signals Regulated by Members of the Rho Family of GTPases
por: Clark, Edwin A., et al.
Publicado: (1998)

Novel Roles for α3β1 Integrin as a Regulator of Cytoskeletal Assembly and as a Trans-dominant Inhibitor of Integrin Receptor Function in Mouse Keratinocytes
por: Hodivala-Dilke, Kairbaan M., et al.
Publicado: (1998)

Mena binds α5 integrin directly and modulates α5β1 function
por: Gupton, Stephanie L., et al.
Publicado: (2012)

Dystrophic Muscle in Mice Chimeric for Expression of α5 Integrin
por: Taverna, Daniela, et al.
Publicado: (1998)

Ablation of β1 integrin in mammary epithelium reveals a key role for integrin in glandular morphogenesis and differentiation
por: Naylor, Matthew J., et al.
Publicado: (2005)

Integrins and extracellular matrix proteins modulate adipocyte thermogenic capacity
por: Gonzalez Porras, Maria A., et al.
Publicado: (2021)

α3β1 Integrin Is Required for Normal Development of the Epidermal Basement Membrane
por: DiPersio, C. Michael, et al.
Publicado: (1997)

Integrins and p53 pathways in glioblastoma resistance to temozolomide
por: Martin, Sophie, et al.
Publicado: (2012)

A Chemically Cross-Linked Knottin Dimer Binds Integrins with Picomolar Affinity and Inhibits Tumor Cell Migration and Proliferation
por: Kim, Jun W., et al.
Publicado: (2014)

Rab25 regulates integrin expression in polarized colonic epithelial cells
por: Krishnan, Moorthy, et al.
Publicado: (2013)

Integrins and cadherins as therapeutic targets in fibrosis
por: Agarwal, Sandeep K.
Publicado: (2014)

An affinity threshold for maximum efficacy in anti-PD-1 immunotherapy
por: Cowles, Sarah C., et al.
Publicado: (2022)

Tumor-localized catalases can fail to alter tumor growth and transcriptional profiles in subcutaneous syngeneic mouse tumor models
por: Sheen, Allison, et al.
Publicado: (2023)

Assessment of US Radiology Residency Program Websites in the COVID-19 Era
por: Liu, David S., et al.
Publicado: (2022)

Targeting Gα(13)-integrin interaction ameliorates systemic inflammation
por: Cheng, Ni, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_5p71q9f3jvik1magj0rjomrkes