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NLRP3 inflammasome assembly is regulated by phosphorylation of the pyrin domain

NLRP3 is a cytosolic pattern recognition receptor that senses microbes and endogenous danger signals. Upon activation, NLRP3 forms an inflammasome with the adapter ASC, resulting in caspase-1 activation, release of proinflammatory cytokines and cell death. How NLRP3 activation is regulated by transc...

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Detalles Bibliográficos
Autores principales:	Stutz, Andrea, Kolbe, Carl-Christian, Stahl, Rainer, Horvath, Gabor L., Franklin, Bernardo S., van Ray, Olivia, Brinkschulte, Rebecca, Geyer, Matthias, Meissner, Felix, Latz, Eicke
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2017
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460996/ https://www.ncbi.nlm.nih.gov/pubmed/28465465 http://dx.doi.org/10.1084/jem.20160933

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