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NLRP3 signaling drives macrophage-induced adaptive immune suppression in pancreatic carcinoma

The tumor microenvironment (TME) in pancreatic ductal adenocarcinoma (PDA) is characterized by immune tolerance, which enables disease to progress unabated by adaptive immunity. However, the drivers of this tolerogenic program are incompletely defined. In this study, we found that NLRP3 promotes exp...

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Detalles Bibliográficos
Autores principales:	Daley, Donnele, Mani, Vishnu R., Mohan, Navyatha, Akkad, Neha, Pandian, Gautam S.D. Balasubramania, Savadkar, Shivraj, Lee, Ki Buom, Torres-Hernandez, Alejandro, Aykut, Berk, Diskin, Brian, Wang, Wei, Farooq, Mohammad S., Mahmud, Arif I., Werba, Gregor, Morales, Eduardo J., Lall, Sarah, Wadowski, Benjamin J., Rubin, Amanda G., Berman, Matthew E., Narayanan, Rajkishen, Hundeyin, Mautin, Miller, George
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2017
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5461004/ https://www.ncbi.nlm.nih.gov/pubmed/28442553 http://dx.doi.org/10.1084/jem.20161707

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