NPM1 directs PIDDosome-dependent caspase-2 activation in the nucleolus

The PIDDosome (PIDD–RAIDD–caspase-2 complex) is considered to be the primary signaling platform for caspase-2 activation in response to genotoxic stress. Yet studies of PIDD-deficient mice show that caspase-2 activation can proceed in the absence of PIDD. Here we show that DNA damage induces the ass...

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Detalles Bibliográficos
Autores principales: Ando, Kiyohiro, Parsons, Melissa J., Shah, Richa B., Charendoff, Chloé I., Paris, Sheré L., Liu, Peter H., Fassio, Sara R., Rohrman, Brittany A., Thompson, Ruth, Oberst, Andrew, Sidi, Samuel, Bouchier-Hayes, Lisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5461015/
https://www.ncbi.nlm.nih.gov/pubmed/28432080
http://dx.doi.org/10.1083/jcb.201608095

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