Nucleolar caspase-2: Protecting us from DNA damage

Caspase-2 triggers apoptosis, but how it is activated by different stimuli is unclear. In this issue, Ando et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201608095) delineate two pathways of caspase-2 activation and show that, in response to DNA damage, caspase-2 forms a complex with the PI...

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Detalles Bibliográficos
Autores principales: O’Byrne, Kenneth J., Richard, Derek J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2017
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5461038/
https://www.ncbi.nlm.nih.gov/pubmed/28500181
http://dx.doi.org/10.1083/jcb.201704114
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author O’Byrne, Kenneth J.
Richard, Derek J.
author_facet O’Byrne, Kenneth J.
Richard, Derek J.
author_sort O’Byrne, Kenneth J.
collection PubMed
description Caspase-2 triggers apoptosis, but how it is activated by different stimuli is unclear. In this issue, Ando et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201608095) delineate two pathways of caspase-2 activation and show that, in response to DNA damage, caspase-2 forms a complex with the PIDDosome and NPM1 within the nucleolus.
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spelling pubmed-54610382017-12-05 Nucleolar caspase-2: Protecting us from DNA damage O’Byrne, Kenneth J. Richard, Derek J. J Cell Biol Commentary Caspase-2 triggers apoptosis, but how it is activated by different stimuli is unclear. In this issue, Ando et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201608095) delineate two pathways of caspase-2 activation and show that, in response to DNA damage, caspase-2 forms a complex with the PIDDosome and NPM1 within the nucleolus. The Rockefeller University Press 2017-06-05 /pmc/articles/PMC5461038/ /pubmed/28500181 http://dx.doi.org/10.1083/jcb.201704114 Text en © 2017 O'Byrne and Richard http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Commentary
O’Byrne, Kenneth J.
Richard, Derek J.
Nucleolar caspase-2: Protecting us from DNA damage
title Nucleolar caspase-2: Protecting us from DNA damage
title_full Nucleolar caspase-2: Protecting us from DNA damage
title_fullStr Nucleolar caspase-2: Protecting us from DNA damage
title_full_unstemmed Nucleolar caspase-2: Protecting us from DNA damage
title_short Nucleolar caspase-2: Protecting us from DNA damage
title_sort nucleolar caspase-2: protecting us from dna damage
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5461038/
https://www.ncbi.nlm.nih.gov/pubmed/28500181
http://dx.doi.org/10.1083/jcb.201704114
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