Structure analyses reveal a regulated oligomerization mechanism of the PlexinD1/GIPC/myosin VI complex

The GIPC family adaptor proteins mediate endocytosis by tethering cargo proteins to the myosin VI motor. The structural mechanisms for the GIPC/cargo and GIPC/myosin VI interactions remained unclear. PlexinD1, a transmembrane receptor that regulates neuronal and cardiovascular development, is a carg...

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Detalles Bibliográficos
Autores principales: Shang, Guijun, Brautigam, Chad A, Chen, Rui, Lu, Defen, Torres-Vázquez, Jesús, Zhang, Xuewu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Biophysics and Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5461112/
https://www.ncbi.nlm.nih.gov/pubmed/28537552
http://dx.doi.org/10.7554/eLife.27322

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5461112/
https://www.ncbi.nlm.nih.gov/pubmed/28537552
http://dx.doi.org/10.7554/eLife.27322

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