Silent Hippocampal Seizures and Spikes Identified by Foramen Ovale Electrodes in Alzheimer’s Disease

We directly assessed mesial temporal activity in two Alzheimer’s disease (AD) patients without a history or EEG evidence of seizures, using intracranial foramen ovale electrodes. We detected clinically silent hippocampal seizures and epileptiform spikes during sleep, a period when both were most lik...

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Autores principales: Lam, Alice D., Deck, Gina, Goldman, Alica, Eskandar, Emad N., Noebels, Jeffrey, Cole, Andrew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5461182/
https://www.ncbi.nlm.nih.gov/pubmed/28459436
http://dx.doi.org/10.1038/nm.4330
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author Lam, Alice D.
Deck, Gina
Goldman, Alica
Eskandar, Emad N.
Noebels, Jeffrey
Cole, Andrew J.
author_facet Lam, Alice D.
Deck, Gina
Goldman, Alica
Eskandar, Emad N.
Noebels, Jeffrey
Cole, Andrew J.
author_sort Lam, Alice D.
collection PubMed
description We directly assessed mesial temporal activity in two Alzheimer’s disease (AD) patients without a history or EEG evidence of seizures, using intracranial foramen ovale electrodes. We detected clinically silent hippocampal seizures and epileptiform spikes during sleep, a period when both were most likely to interfere with memory consolidation. These index cases support a model in which early development of occult hippocampal hyperexcitability may contribute to the pathogenesis of AD.
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spelling pubmed-54611822017-11-01 Silent Hippocampal Seizures and Spikes Identified by Foramen Ovale Electrodes in Alzheimer’s Disease Lam, Alice D. Deck, Gina Goldman, Alica Eskandar, Emad N. Noebels, Jeffrey Cole, Andrew J. Nat Med Article We directly assessed mesial temporal activity in two Alzheimer’s disease (AD) patients without a history or EEG evidence of seizures, using intracranial foramen ovale electrodes. We detected clinically silent hippocampal seizures and epileptiform spikes during sleep, a period when both were most likely to interfere with memory consolidation. These index cases support a model in which early development of occult hippocampal hyperexcitability may contribute to the pathogenesis of AD. 2017-05-01 2017-06 /pmc/articles/PMC5461182/ /pubmed/28459436 http://dx.doi.org/10.1038/nm.4330 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Lam, Alice D.
Deck, Gina
Goldman, Alica
Eskandar, Emad N.
Noebels, Jeffrey
Cole, Andrew J.
Silent Hippocampal Seizures and Spikes Identified by Foramen Ovale Electrodes in Alzheimer’s Disease
title Silent Hippocampal Seizures and Spikes Identified by Foramen Ovale Electrodes in Alzheimer’s Disease
title_full Silent Hippocampal Seizures and Spikes Identified by Foramen Ovale Electrodes in Alzheimer’s Disease
title_fullStr Silent Hippocampal Seizures and Spikes Identified by Foramen Ovale Electrodes in Alzheimer’s Disease
title_full_unstemmed Silent Hippocampal Seizures and Spikes Identified by Foramen Ovale Electrodes in Alzheimer’s Disease
title_short Silent Hippocampal Seizures and Spikes Identified by Foramen Ovale Electrodes in Alzheimer’s Disease
title_sort silent hippocampal seizures and spikes identified by foramen ovale electrodes in alzheimer’s disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5461182/
https://www.ncbi.nlm.nih.gov/pubmed/28459436
http://dx.doi.org/10.1038/nm.4330
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