ADAR1 controls apoptosis of stressed cells by inhibiting Staufen1-mediated mRNA decay

Both p150 and p110 isoforms of ADAR1 convert adenosine to inosine in double-stranded RNA (dsRNA). ADAR1p150 suppresses the dsRNA sensing mechanism that activates MDA5-MAVS-IFN signaling in the cytoplasm. In contrast, the biological function of the ADAR1p110 isoform, usually located in the nucleus, r...

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Detalles Bibliográficos
Autores principales: Sakurai, Masayuki, Shiromoto, Yusuke, Ota, Hiromitsu, Song, Chunzi, Kossenkov, Andrew V., Wickramasinghe, Jayamanna, Showe, Louise C., Skordalakes, Emmanuel, Tang, Hsin-Yao, Speicher, David W., Nishikura, Kazuko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5461201/
https://www.ncbi.nlm.nih.gov/pubmed/28436945
http://dx.doi.org/10.1038/nsmb.3403

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5461201/
https://www.ncbi.nlm.nih.gov/pubmed/28436945
http://dx.doi.org/10.1038/nsmb.3403

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