Graft-versus-Leukemia Effect Following Hematopoietic Stem Cell Transplantation for Leukemia

The success of hematopoietic stem cell transplantation (HSCT) lies with the ability of the engrafting immune system to remove residual leukemia cells via a graft-versus-leukemia effect (GvL), caused either spontaneously post-HSCT or via donor lymphocyte infusion. GvL effects can also be initiated by...

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Detalles Bibliográficos
Autores principales: Dickinson, Anne M., Norden, Jean, Li, Shuang, Hromadnikova, Ilona, Schmid, Christoph, Schmetzer, Helga, Jochem-Kolb, Hans
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5461268/
https://www.ncbi.nlm.nih.gov/pubmed/28638379
http://dx.doi.org/10.3389/fimmu.2017.00496
Descripción
Sumario:The success of hematopoietic stem cell transplantation (HSCT) lies with the ability of the engrafting immune system to remove residual leukemia cells via a graft-versus-leukemia effect (GvL), caused either spontaneously post-HSCT or via donor lymphocyte infusion. GvL effects can also be initiated by allogenic mismatched natural killer cells, antigen-specific T cells, and activated dendritic cells of leukemic origin. The history and further application of this GvL effect and the main mechanisms will be discussed and reviewed in this chapter.

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