Graft-versus-Leukemia Effect Following Hematopoietic Stem Cell Transplantation for Leukemia

The success of hematopoietic stem cell transplantation (HSCT) lies with the ability of the engrafting immune system to remove residual leukemia cells via a graft-versus-leukemia effect (GvL), caused either spontaneously post-HSCT or via donor lymphocyte infusion. GvL effects can also be initiated by...

Descripción completa

Detalles Bibliográficos
Autores principales: Dickinson, Anne M., Norden, Jean, Li, Shuang, Hromadnikova, Ilona, Schmid, Christoph, Schmetzer, Helga, Jochem-Kolb, Hans
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5461268/
https://www.ncbi.nlm.nih.gov/pubmed/28638379
http://dx.doi.org/10.3389/fimmu.2017.00496
_version_ 1783242303221006336
author Dickinson, Anne M.
Norden, Jean
Li, Shuang
Hromadnikova, Ilona
Schmid, Christoph
Schmetzer, Helga
Jochem-Kolb, Hans
author_facet Dickinson, Anne M.
Norden, Jean
Li, Shuang
Hromadnikova, Ilona
Schmid, Christoph
Schmetzer, Helga
Jochem-Kolb, Hans
author_sort Dickinson, Anne M.
collection PubMed
description The success of hematopoietic stem cell transplantation (HSCT) lies with the ability of the engrafting immune system to remove residual leukemia cells via a graft-versus-leukemia effect (GvL), caused either spontaneously post-HSCT or via donor lymphocyte infusion. GvL effects can also be initiated by allogenic mismatched natural killer cells, antigen-specific T cells, and activated dendritic cells of leukemic origin. The history and further application of this GvL effect and the main mechanisms will be discussed and reviewed in this chapter.
format Online
Article
Text
id pubmed-5461268
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-54612682017-06-21 Graft-versus-Leukemia Effect Following Hematopoietic Stem Cell Transplantation for Leukemia Dickinson, Anne M. Norden, Jean Li, Shuang Hromadnikova, Ilona Schmid, Christoph Schmetzer, Helga Jochem-Kolb, Hans Front Immunol Immunology The success of hematopoietic stem cell transplantation (HSCT) lies with the ability of the engrafting immune system to remove residual leukemia cells via a graft-versus-leukemia effect (GvL), caused either spontaneously post-HSCT or via donor lymphocyte infusion. GvL effects can also be initiated by allogenic mismatched natural killer cells, antigen-specific T cells, and activated dendritic cells of leukemic origin. The history and further application of this GvL effect and the main mechanisms will be discussed and reviewed in this chapter. Frontiers Media S.A. 2017-06-07 /pmc/articles/PMC5461268/ /pubmed/28638379 http://dx.doi.org/10.3389/fimmu.2017.00496 Text en Copyright © 2017 Dickinson, Norden, Li, Hromadnikova, Schmid, Schmetzer and Jochem-Kolb. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Dickinson, Anne M.
Norden, Jean
Li, Shuang
Hromadnikova, Ilona
Schmid, Christoph
Schmetzer, Helga
Jochem-Kolb, Hans
Graft-versus-Leukemia Effect Following Hematopoietic Stem Cell Transplantation for Leukemia
title Graft-versus-Leukemia Effect Following Hematopoietic Stem Cell Transplantation for Leukemia
title_full Graft-versus-Leukemia Effect Following Hematopoietic Stem Cell Transplantation for Leukemia
title_fullStr Graft-versus-Leukemia Effect Following Hematopoietic Stem Cell Transplantation for Leukemia
title_full_unstemmed Graft-versus-Leukemia Effect Following Hematopoietic Stem Cell Transplantation for Leukemia
title_short Graft-versus-Leukemia Effect Following Hematopoietic Stem Cell Transplantation for Leukemia
title_sort graft-versus-leukemia effect following hematopoietic stem cell transplantation for leukemia
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5461268/
https://www.ncbi.nlm.nih.gov/pubmed/28638379
http://dx.doi.org/10.3389/fimmu.2017.00496
work_keys_str_mv AT dickinsonannem graftversusleukemiaeffectfollowinghematopoieticstemcelltransplantationforleukemia
AT nordenjean graftversusleukemiaeffectfollowinghematopoieticstemcelltransplantationforleukemia
AT lishuang graftversusleukemiaeffectfollowinghematopoieticstemcelltransplantationforleukemia
AT hromadnikovailona graftversusleukemiaeffectfollowinghematopoieticstemcelltransplantationforleukemia
AT schmidchristoph graftversusleukemiaeffectfollowinghematopoieticstemcelltransplantationforleukemia
AT schmetzerhelga graftversusleukemiaeffectfollowinghematopoieticstemcelltransplantationforleukemia
AT jochemkolbhans graftversusleukemiaeffectfollowinghematopoieticstemcelltransplantationforleukemia

Ejemplares similares