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Differential activation of DNA-PK based on DNA strand orientation and sequence bias

DNA-PKcs and Ku are essential components of the complex that catalyzes non-homologous end joining (NHEJ) of DNA double-strand breaks (DSBs). Ku, a heterodimeric protein, binds to DNA ends and facilitates recruitment of the catalytic subunit, DNA-PKcs. We have investigated the effect of DNA strand or...

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Detalles Bibliográficos
Autores principales:	Pawelczak, Katherine S., Andrews, Brooke J., Turchi, John J.
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2005
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC546145/ https://www.ncbi.nlm.nih.gov/pubmed/15640450 http://dx.doi.org/10.1093/nar/gki157

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