Tumour-associated macrophages secrete pleiotrophin to promote PTPRZ1 signalling in glioblastoma stem cells for tumour growth

Intense infiltration of tumour-associated macrophages (TAMs) facilitates malignant growth of glioblastoma (GBM), but the underlying mechanisms remain undefined. Herein, we report that TAMs secrete abundant pleiotrophin (PTN) to stimulate glioma stem cells (GSCs) through its receptor PTPRZ1 thus prom...

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Detalles Bibliográficos
Autores principales: Shi, Yu, Ping, Yi-Fang, Zhou, Wenchao, He, Zhi-Cheng, Chen, Cong, Bian, Bai-Shi-Jiao, Zhang, Lin, Chen, Lu, Lan, Xun, Zhang, Xian-Chao, Zhou, Kai, Liu, Qing, Long, Hua, Fu, Ti-Wei, Zhang, Xiao-Ning, Cao, Mian-Fu, Huang, Zhi, Fang, Xiaoguang, Wang, Xiuxing, Feng, Hua, Yao, Xiao-Hong, Yu, Shi-Cang, Cui, You-Hong, Zhang, Xia, Rich, Jeremy N, Bao, Shideng, Bian, Xiu-Wu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5461490/
https://www.ncbi.nlm.nih.gov/pubmed/28569747
http://dx.doi.org/10.1038/ncomms15080

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