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Processing of a complex multiply damaged DNA site by human cell extracts and purified repair proteins

Clustered DNA lesions, possibly induced by ionizing radiation, constitute a trial for repair processes. Indeed, recent studies suggest that repair of such lesions may be compromised, potentially leading to the formation of lethal double-strand breaks (DSBs). A complex multiply damaged site (MDS) com...

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Detalles Bibliográficos
Autores principales: Eot-Houllier, Grégory, Eon-Marchais, Séverine, Gasparutto, Didier, Sage, Evelyne
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2005
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC546153/
https://www.ncbi.nlm.nih.gov/pubmed/15647508
http://dx.doi.org/10.1093/nar/gki165