MOB1 Mediated Phospho-recognition in the Core Mammalian Hippo Pathway

The Hippo tumor suppressor pathway regulates organ size and tissue homoeostasis in response to diverse signaling inputs. The core of the pathway consists of a short kinase cascade: MST1 and MST2 phosphorylate and activate LATS1 and LATS2, which in turn phosphorylate and inactivate key transcriptiona...

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Detalles Bibliográficos
Autores principales: Couzens, Amber L., Xiong, Shawn, Knight, James D. R., Mao, Daniel Y., Guettler, Sebastian, Picaud, Sarah, Kurinov, Igor, Filippakopoulos, Panagis, Sicheri, Frank, Gingras, Anne-Claude
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Biochemistry and Molecular Biology 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5461540/
https://www.ncbi.nlm.nih.gov/pubmed/28373298
http://dx.doi.org/10.1074/mcp.M116.065490

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