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Molecular biology of frozen shoulder-induced limitation of shoulder joint movements

Frozen shoulder is a chronic condition characterized by pain in the shoulder and restriction of movements in all directions. Some patients are left with long-term limitation of shoulder joint activity with various severities, which results in reduced quality of life. Currently, there is a paucity of...

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Autores principales: Cui, Jiaming, Lu, Wei, He, Yong, Jiang, Luoyong, Li, Kuokuo, Zhu, Weimin, Wang, Daping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5461583/
https://www.ncbi.nlm.nih.gov/pubmed/28616048
http://dx.doi.org/10.4103/jrms.JRMS_1005_16
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author Cui, Jiaming
Lu, Wei
He, Yong
Jiang, Luoyong
Li, Kuokuo
Zhu, Weimin
Wang, Daping
author_facet Cui, Jiaming
Lu, Wei
He, Yong
Jiang, Luoyong
Li, Kuokuo
Zhu, Weimin
Wang, Daping
author_sort Cui, Jiaming
collection PubMed
description Frozen shoulder is a chronic condition characterized by pain in the shoulder and restriction of movements in all directions. Some patients are left with long-term limitation of shoulder joint activity with various severities, which results in reduced quality of life. Currently, there is a paucity of literature on the molecular biology of frozen shoulder, and the molecular biological mechanism for periarthritis-induced limitation of shoulder joint movements remains unclear. Research in this field is focused on inflammation and cytokines associated with fibrosis. Repeated investigations confirmed alterations of specified inflammatory mediators and fibrosis-associated cytokines, which might be involved in the pathogenesis of frozen shoulder by causing structural changes of the shoulder joint and eventually the limitation of shoulder movements. The aim of this article is to review studies on molecular biology of frozen shoulder and provide a reference for subsequent research, treatment, and development of new drugs.
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spelling pubmed-54615832017-06-14 Molecular biology of frozen shoulder-induced limitation of shoulder joint movements Cui, Jiaming Lu, Wei He, Yong Jiang, Luoyong Li, Kuokuo Zhu, Weimin Wang, Daping J Res Med Sci Review Article Frozen shoulder is a chronic condition characterized by pain in the shoulder and restriction of movements in all directions. Some patients are left with long-term limitation of shoulder joint activity with various severities, which results in reduced quality of life. Currently, there is a paucity of literature on the molecular biology of frozen shoulder, and the molecular biological mechanism for periarthritis-induced limitation of shoulder joint movements remains unclear. Research in this field is focused on inflammation and cytokines associated with fibrosis. Repeated investigations confirmed alterations of specified inflammatory mediators and fibrosis-associated cytokines, which might be involved in the pathogenesis of frozen shoulder by causing structural changes of the shoulder joint and eventually the limitation of shoulder movements. The aim of this article is to review studies on molecular biology of frozen shoulder and provide a reference for subsequent research, treatment, and development of new drugs. Medknow Publications & Media Pvt Ltd 2017-05-30 /pmc/articles/PMC5461583/ /pubmed/28616048 http://dx.doi.org/10.4103/jrms.JRMS_1005_16 Text en Copyright: © 2017 Journal of Research in Medical Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Review Article
Cui, Jiaming
Lu, Wei
He, Yong
Jiang, Luoyong
Li, Kuokuo
Zhu, Weimin
Wang, Daping
Molecular biology of frozen shoulder-induced limitation of shoulder joint movements
title Molecular biology of frozen shoulder-induced limitation of shoulder joint movements
title_full Molecular biology of frozen shoulder-induced limitation of shoulder joint movements
title_fullStr Molecular biology of frozen shoulder-induced limitation of shoulder joint movements
title_full_unstemmed Molecular biology of frozen shoulder-induced limitation of shoulder joint movements
title_short Molecular biology of frozen shoulder-induced limitation of shoulder joint movements
title_sort molecular biology of frozen shoulder-induced limitation of shoulder joint movements
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5461583/
https://www.ncbi.nlm.nih.gov/pubmed/28616048
http://dx.doi.org/10.4103/jrms.JRMS_1005_16
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