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Single-cell entropy for accurate estimation of differentiation potency from a cell's transcriptome
The ability to quantify differentiation potential of single cells is a task of critical importance. Here we demonstrate, using over 7,000 single-cell RNA-Seq profiles, that differentiation potency of a single cell can be approximated by computing the signalling promiscuity, or entropy, of a cell...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5461595/ https://www.ncbi.nlm.nih.gov/pubmed/28569836 http://dx.doi.org/10.1038/ncomms15599 |