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Glutaminyl cyclase activity correlates with levels of Aβ peptides and mediators of angiogenesis in cerebrospinal fluid of Alzheimer’s disease patients

BACKGROUND: Pyroglutamylation of truncated Aβ peptides, which is catalysed by enzyme glutaminyl cyclase (QC), generates pE-Aβ species with enhanced aggregation propensities and resistance to most amino-peptidases and endo-peptidases. pE-Aβ species have been identified as major constituents of Aβ pla...

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Detalles Bibliográficos
Autores principales:	Bridel, Claire, Hoffmann, Torsten, Meyer, Antje, Durieux, Sisi, Koel-Simmelink, Marleen A., Orth, Matthias, Scheltens, Philip, Lues, Inge, Teunissen, Charlotte E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5461753/ https://www.ncbi.nlm.nih.gov/pubmed/28587659 http://dx.doi.org/10.1186/s13195-017-0266-6

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