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Small-cell neuroendocrine carcinoma of the esophagus: an autopsy case report

Small-cell neuroendocrine carcinoma is a well-known aggressive neoplasia, which is usually associated with a poor prognosis. The lung is the most common primary site, but other organs may be involved, especially those of the digestive tract. The authors report the case of a 71-year-old Caucasian, ma...

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Autores principales: Sepulvida, Mariana Bellaguarda de Castro, Amaral, Augusto Vieira, de Campos, Pompeu Tomé Ribeiro, Teixeira, Carlos Osvaldo, Teixeira, Maria Aparecida Barone
Formato: Online Artículo Texto
Lenguaje:English
Publicado: São Paulo, SP: Universidade de São Paulo, Hospital Universitário 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5461825/
https://www.ncbi.nlm.nih.gov/pubmed/28652988
http://dx.doi.org/10.4322/acr.2014.003
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author Sepulvida, Mariana Bellaguarda de Castro
Amaral, Augusto Vieira
de Campos, Pompeu Tomé Ribeiro
Teixeira, Carlos Osvaldo
Teixeira, Maria Aparecida Barone
author_facet Sepulvida, Mariana Bellaguarda de Castro
Amaral, Augusto Vieira
de Campos, Pompeu Tomé Ribeiro
Teixeira, Carlos Osvaldo
Teixeira, Maria Aparecida Barone
author_sort Sepulvida, Mariana Bellaguarda de Castro
collection PubMed
description Small-cell neuroendocrine carcinoma is a well-known aggressive neoplasia, which is usually associated with a poor prognosis. The lung is the most common primary site, but other organs may be involved, especially those of the digestive tract. The authors report the case of a 71-year-old Caucasian, male patient who was admitted because of congestive heart failure and loss of vision accompanied by right proptosis. Skull and sinuses computed tomography showed a tumoral mass involving the posterior region of the right eye, local bones, and paranasal sinuses. Because of severe hemodynamic instability, the patient died and no diagnostic investigation could be performed. Autopsy findings revealed small-cell neuroendocrine carcinoma of the esophagus and metastases to the posterior region of the right ocular globe, which affected the sinuses, the muscles of the ocular region, the orbit bones, the skull, the meninges and the brain, plus the liver, adrenal glands, and the pericardium. This case called the author’s attention to the extent of the metastatic disease in a patient who was firstly interpreted as presenting solely with congestive heart failure. The autopsy findings substantially aid the understanding of the immediate cause of death.
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spelling pubmed-54618252017-06-26 Small-cell neuroendocrine carcinoma of the esophagus: an autopsy case report Sepulvida, Mariana Bellaguarda de Castro Amaral, Augusto Vieira de Campos, Pompeu Tomé Ribeiro Teixeira, Carlos Osvaldo Teixeira, Maria Aparecida Barone Autops Case Rep Article / Autopsy Case Report Small-cell neuroendocrine carcinoma is a well-known aggressive neoplasia, which is usually associated with a poor prognosis. The lung is the most common primary site, but other organs may be involved, especially those of the digestive tract. The authors report the case of a 71-year-old Caucasian, male patient who was admitted because of congestive heart failure and loss of vision accompanied by right proptosis. Skull and sinuses computed tomography showed a tumoral mass involving the posterior region of the right eye, local bones, and paranasal sinuses. Because of severe hemodynamic instability, the patient died and no diagnostic investigation could be performed. Autopsy findings revealed small-cell neuroendocrine carcinoma of the esophagus and metastases to the posterior region of the right ocular globe, which affected the sinuses, the muscles of the ocular region, the orbit bones, the skull, the meninges and the brain, plus the liver, adrenal glands, and the pericardium. This case called the author’s attention to the extent of the metastatic disease in a patient who was firstly interpreted as presenting solely with congestive heart failure. The autopsy findings substantially aid the understanding of the immediate cause of death. São Paulo, SP: Universidade de São Paulo, Hospital Universitário 2014-03-31 /pmc/articles/PMC5461825/ /pubmed/28652988 http://dx.doi.org/10.4322/acr.2014.003 Text en Copyright © 2014 Autopsy and Case Reports http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed of terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium provided article is properly cited.
spellingShingle Article / Autopsy Case Report
Sepulvida, Mariana Bellaguarda de Castro
Amaral, Augusto Vieira
de Campos, Pompeu Tomé Ribeiro
Teixeira, Carlos Osvaldo
Teixeira, Maria Aparecida Barone
Small-cell neuroendocrine carcinoma of the esophagus: an autopsy case report
title Small-cell neuroendocrine carcinoma of the esophagus: an autopsy case report
title_full Small-cell neuroendocrine carcinoma of the esophagus: an autopsy case report
title_fullStr Small-cell neuroendocrine carcinoma of the esophagus: an autopsy case report
title_full_unstemmed Small-cell neuroendocrine carcinoma of the esophagus: an autopsy case report
title_short Small-cell neuroendocrine carcinoma of the esophagus: an autopsy case report
title_sort small-cell neuroendocrine carcinoma of the esophagus: an autopsy case report
topic Article / Autopsy Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5461825/
https://www.ncbi.nlm.nih.gov/pubmed/28652988
http://dx.doi.org/10.4322/acr.2014.003
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