Elevated Spontaneous Interferon-γ Secretion in Human Immunodeficiency Virus-Infected Persons

Immune activation in human immunodeficiency virus (HIV) is a well described phenomenon. We found that HIV patients have higher secretion of interferon (IFN)-γ compared with non-HIV subjects, as measured by the “nil” value in the QuantiFERON-TB Gold test, even when viral loads are low. This may refle...

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Detalles Bibliográficos
Autores principales: Sparks, Rachel, Koelle, David M., Stern, Joshua E., Dhanireddy, Shireesha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5461986/
https://www.ncbi.nlm.nih.gov/pubmed/28616443
http://dx.doi.org/10.1093/ofid/ofx055
Descripción
Sumario:Immune activation in human immunodeficiency virus (HIV) is a well described phenomenon. We found that HIV patients have higher secretion of interferon (IFN)-γ compared with non-HIV subjects, as measured by the “nil” value in the QuantiFERON-TB Gold test, even when viral loads are low. This may reflect ongoing immune activation, even with optimal HIV management.

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