Elevated Spontaneous Interferon-γ Secretion in Human Immunodeficiency Virus-Infected Persons

Immune activation in human immunodeficiency virus (HIV) is a well described phenomenon. We found that HIV patients have higher secretion of interferon (IFN)-γ compared with non-HIV subjects, as measured by the “nil” value in the QuantiFERON-TB Gold test, even when viral loads are low. This may refle...

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Detalles Bibliográficos
Autores principales: Sparks, Rachel, Koelle, David M., Stern, Joshua E., Dhanireddy, Shireesha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5461986/
https://www.ncbi.nlm.nih.gov/pubmed/28616443
http://dx.doi.org/10.1093/ofid/ofx055
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author Sparks, Rachel
Koelle, David M.
Stern, Joshua E.
Dhanireddy, Shireesha
author_facet Sparks, Rachel
Koelle, David M.
Stern, Joshua E.
Dhanireddy, Shireesha
author_sort Sparks, Rachel
collection PubMed
description Immune activation in human immunodeficiency virus (HIV) is a well described phenomenon. We found that HIV patients have higher secretion of interferon (IFN)-γ compared with non-HIV subjects, as measured by the “nil” value in the QuantiFERON-TB Gold test, even when viral loads are low. This may reflect ongoing immune activation, even with optimal HIV management.
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spelling pubmed-54619862017-06-14 Elevated Spontaneous Interferon-γ Secretion in Human Immunodeficiency Virus-Infected Persons Sparks, Rachel Koelle, David M. Stern, Joshua E. Dhanireddy, Shireesha Open Forum Infect Dis Brief Report Immune activation in human immunodeficiency virus (HIV) is a well described phenomenon. We found that HIV patients have higher secretion of interferon (IFN)-γ compared with non-HIV subjects, as measured by the “nil” value in the QuantiFERON-TB Gold test, even when viral loads are low. This may reflect ongoing immune activation, even with optimal HIV management. Oxford University Press 2017-06-07 /pmc/articles/PMC5461986/ /pubmed/28616443 http://dx.doi.org/10.1093/ofid/ofx055 Text en © The Author 2017. Published by Oxford University Press on behalf of Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Brief Report
Sparks, Rachel
Koelle, David M.
Stern, Joshua E.
Dhanireddy, Shireesha
Elevated Spontaneous Interferon-γ Secretion in Human Immunodeficiency Virus-Infected Persons
title Elevated Spontaneous Interferon-γ Secretion in Human Immunodeficiency Virus-Infected Persons
title_full Elevated Spontaneous Interferon-γ Secretion in Human Immunodeficiency Virus-Infected Persons
title_fullStr Elevated Spontaneous Interferon-γ Secretion in Human Immunodeficiency Virus-Infected Persons
title_full_unstemmed Elevated Spontaneous Interferon-γ Secretion in Human Immunodeficiency Virus-Infected Persons
title_short Elevated Spontaneous Interferon-γ Secretion in Human Immunodeficiency Virus-Infected Persons
title_sort elevated spontaneous interferon-γ secretion in human immunodeficiency virus-infected persons
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5461986/
https://www.ncbi.nlm.nih.gov/pubmed/28616443
http://dx.doi.org/10.1093/ofid/ofx055
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