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Analysis of various potential prognostic markers and survival data in clear cell renal cell carcinoma
PURPOSE: Clear cell renal cell cancers frequently harbor Von Hippel-Lindau gene mutations, leading to stabilization of the hypoxia-inducible factors (HIFs) and their target genes. In this study, we investigated the relationship between vascular endothelial growth factor (VEGF), HIF-1α, HIF-2α, p53 p...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sociedade Brasileira de Urologia
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5462134/ https://www.ncbi.nlm.nih.gov/pubmed/27583351 http://dx.doi.org/10.1590/S1677-5538.IBJU.2015.0521 |
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author | Ebru, Tastekin Fulya, Oz Puyan Hakan, Akdere Vuslat, Yurut-Caloglu Necdet, Sut Nuray, Can Filiz, Ozyilmaz |
author_facet | Ebru, Tastekin Fulya, Oz Puyan Hakan, Akdere Vuslat, Yurut-Caloglu Necdet, Sut Nuray, Can Filiz, Ozyilmaz |
author_sort | Ebru, Tastekin |
collection | PubMed |
description | PURPOSE: Clear cell renal cell cancers frequently harbor Von Hippel-Lindau gene mutations, leading to stabilization of the hypoxia-inducible factors (HIFs) and their target genes. In this study, we investigated the relationship between vascular endothelial growth factor (VEGF), HIF-1α, HIF-2α, p53 positivity, microvessel density, and Ki-67 rates with prognostic histopathologic factors (Fuhrman nuclear grade, stage, and sarcomatoid differentiation) and survival in clear cell renal cell carcinomas. MATERIAL AND METHODS: Seventy-two nephrectomy specimens diagnosed as clear cell renal cell carcinoma between 2000 and 2012 were reevaluated. Immunohistochemically VEGF, HIF-1α, HIF-2α, p53, CD34 (for microvessel density evaluation), and Ki-67 antibodies were applied to the tumor areas. The relationships of these antibodies with prognostic factors and survival rates were evaluated with statistical analyses. RESULTS: Mean survival time was 105.6 months in patients with ccRCC. Patients with high expression of VEGF, HIF-1α and HIF-2α positivity, a high Ki-67 proliferation index, and a high microvessel density evaluation score had a shorter survival time (p<0.05). CONCLUSIONS: Our findings supported that with the use of these immunohistochemical markers, prognosis of renal cell carcinoma may be predicted at the first step of patient management. New treatment modalities targeted to HIF-1α and HIF-2α might be planned as well as VEGF-targeted therapies in the management of clear cell renal cell carcinomas. |
format | Online Article Text |
id | pubmed-5462134 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Sociedade Brasileira de Urologia |
record_format | MEDLINE/PubMed |
spelling | pubmed-54621342017-06-19 Analysis of various potential prognostic markers and survival data in clear cell renal cell carcinoma Ebru, Tastekin Fulya, Oz Puyan Hakan, Akdere Vuslat, Yurut-Caloglu Necdet, Sut Nuray, Can Filiz, Ozyilmaz Int Braz J Urol Original Article PURPOSE: Clear cell renal cell cancers frequently harbor Von Hippel-Lindau gene mutations, leading to stabilization of the hypoxia-inducible factors (HIFs) and their target genes. In this study, we investigated the relationship between vascular endothelial growth factor (VEGF), HIF-1α, HIF-2α, p53 positivity, microvessel density, and Ki-67 rates with prognostic histopathologic factors (Fuhrman nuclear grade, stage, and sarcomatoid differentiation) and survival in clear cell renal cell carcinomas. MATERIAL AND METHODS: Seventy-two nephrectomy specimens diagnosed as clear cell renal cell carcinoma between 2000 and 2012 were reevaluated. Immunohistochemically VEGF, HIF-1α, HIF-2α, p53, CD34 (for microvessel density evaluation), and Ki-67 antibodies were applied to the tumor areas. The relationships of these antibodies with prognostic factors and survival rates were evaluated with statistical analyses. RESULTS: Mean survival time was 105.6 months in patients with ccRCC. Patients with high expression of VEGF, HIF-1α and HIF-2α positivity, a high Ki-67 proliferation index, and a high microvessel density evaluation score had a shorter survival time (p<0.05). CONCLUSIONS: Our findings supported that with the use of these immunohistochemical markers, prognosis of renal cell carcinoma may be predicted at the first step of patient management. New treatment modalities targeted to HIF-1α and HIF-2α might be planned as well as VEGF-targeted therapies in the management of clear cell renal cell carcinomas. Sociedade Brasileira de Urologia 2017 /pmc/articles/PMC5462134/ /pubmed/27583351 http://dx.doi.org/10.1590/S1677-5538.IBJU.2015.0521 Text en http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Ebru, Tastekin Fulya, Oz Puyan Hakan, Akdere Vuslat, Yurut-Caloglu Necdet, Sut Nuray, Can Filiz, Ozyilmaz Analysis of various potential prognostic markers and survival data in clear cell renal cell carcinoma |
title | Analysis of various potential prognostic markers and survival data in clear cell renal cell carcinoma |
title_full | Analysis of various potential prognostic markers and survival data in clear cell renal cell carcinoma |
title_fullStr | Analysis of various potential prognostic markers and survival data in clear cell renal cell carcinoma |
title_full_unstemmed | Analysis of various potential prognostic markers and survival data in clear cell renal cell carcinoma |
title_short | Analysis of various potential prognostic markers and survival data in clear cell renal cell carcinoma |
title_sort | analysis of various potential prognostic markers and survival data in clear cell renal cell carcinoma |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5462134/ https://www.ncbi.nlm.nih.gov/pubmed/27583351 http://dx.doi.org/10.1590/S1677-5538.IBJU.2015.0521 |
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