Reanalysis of BRCA1/2 negative high risk ovarian cancer patients reveals novel germline risk loci and insights into missing heritability

While up to 25% of ovarian cancer (OVCA) cases are thought to be due to inherited factors, the majority of genetic risk remains unexplained. To address this gap, we sought to identify previously undescribed OVCA risk variants through the whole exome sequencing (WES) and candidate gene analysis of 48...

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Detalles Bibliográficos
Autores principales: Stafford, Jaime L., Dyson, Gregory, Levin, Nancy K., Chaudhry, Sophia, Rosati, Rita, Kalpage, Hasini, Wernette, Courtney, Petrucelli, Nancie, Simon, Michael S., Tainsky, Michael A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5462348/
https://www.ncbi.nlm.nih.gov/pubmed/28591191
http://dx.doi.org/10.1371/journal.pone.0178450

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