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The Role of Astrocyte Dysfunction in Parkinson’s Disease Pathogenesis

Astrocytes are the most populous glial subtype and are critical for brain function. Despite this, historically there have been few studies into the role that they may have in neurodegenerative diseases, such as Parkinson’s disease (PD). Recently, however, several studies have determined that genes k...

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Detalles Bibliográficos
Autores principales: Booth, Heather D.E., Hirst, Warren D., Wade-Martins, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Applied Science Publishing 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5462417/
https://www.ncbi.nlm.nih.gov/pubmed/28527591
http://dx.doi.org/10.1016/j.tins.2017.04.001
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author Booth, Heather D.E.
Hirst, Warren D.
Wade-Martins, Richard
author_facet Booth, Heather D.E.
Hirst, Warren D.
Wade-Martins, Richard
author_sort Booth, Heather D.E.
collection PubMed
description Astrocytes are the most populous glial subtype and are critical for brain function. Despite this, historically there have been few studies into the role that they may have in neurodegenerative diseases, such as Parkinson’s disease (PD). Recently, however, several studies have determined that genes known to have a causative role in the development of PD are expressed in astrocytes and have important roles in astrocyte function. Here, we review these recent developments and discuss their impact on our understanding of the pathophysiology of PD, and the implications that this might have for its treatment.
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spelling pubmed-54624172017-06-15 The Role of Astrocyte Dysfunction in Parkinson’s Disease Pathogenesis Booth, Heather D.E. Hirst, Warren D. Wade-Martins, Richard Trends Neurosci Review Astrocytes are the most populous glial subtype and are critical for brain function. Despite this, historically there have been few studies into the role that they may have in neurodegenerative diseases, such as Parkinson’s disease (PD). Recently, however, several studies have determined that genes known to have a causative role in the development of PD are expressed in astrocytes and have important roles in astrocyte function. Here, we review these recent developments and discuss their impact on our understanding of the pathophysiology of PD, and the implications that this might have for its treatment. Elsevier Applied Science Publishing 2017-06 /pmc/articles/PMC5462417/ /pubmed/28527591 http://dx.doi.org/10.1016/j.tins.2017.04.001 Text en © 2017 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Booth, Heather D.E.
Hirst, Warren D.
Wade-Martins, Richard
The Role of Astrocyte Dysfunction in Parkinson’s Disease Pathogenesis
title The Role of Astrocyte Dysfunction in Parkinson’s Disease Pathogenesis
title_full The Role of Astrocyte Dysfunction in Parkinson’s Disease Pathogenesis
title_fullStr The Role of Astrocyte Dysfunction in Parkinson’s Disease Pathogenesis
title_full_unstemmed The Role of Astrocyte Dysfunction in Parkinson’s Disease Pathogenesis
title_short The Role of Astrocyte Dysfunction in Parkinson’s Disease Pathogenesis
title_sort role of astrocyte dysfunction in parkinson’s disease pathogenesis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5462417/
https://www.ncbi.nlm.nih.gov/pubmed/28527591
http://dx.doi.org/10.1016/j.tins.2017.04.001
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