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The Role of Astrocyte Dysfunction in Parkinson’s Disease Pathogenesis
Astrocytes are the most populous glial subtype and are critical for brain function. Despite this, historically there have been few studies into the role that they may have in neurodegenerative diseases, such as Parkinson’s disease (PD). Recently, however, several studies have determined that genes k...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Applied Science Publishing
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5462417/ https://www.ncbi.nlm.nih.gov/pubmed/28527591 http://dx.doi.org/10.1016/j.tins.2017.04.001 |
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author | Booth, Heather D.E. Hirst, Warren D. Wade-Martins, Richard |
author_facet | Booth, Heather D.E. Hirst, Warren D. Wade-Martins, Richard |
author_sort | Booth, Heather D.E. |
collection | PubMed |
description | Astrocytes are the most populous glial subtype and are critical for brain function. Despite this, historically there have been few studies into the role that they may have in neurodegenerative diseases, such as Parkinson’s disease (PD). Recently, however, several studies have determined that genes known to have a causative role in the development of PD are expressed in astrocytes and have important roles in astrocyte function. Here, we review these recent developments and discuss their impact on our understanding of the pathophysiology of PD, and the implications that this might have for its treatment. |
format | Online Article Text |
id | pubmed-5462417 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Elsevier Applied Science Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-54624172017-06-15 The Role of Astrocyte Dysfunction in Parkinson’s Disease Pathogenesis Booth, Heather D.E. Hirst, Warren D. Wade-Martins, Richard Trends Neurosci Review Astrocytes are the most populous glial subtype and are critical for brain function. Despite this, historically there have been few studies into the role that they may have in neurodegenerative diseases, such as Parkinson’s disease (PD). Recently, however, several studies have determined that genes known to have a causative role in the development of PD are expressed in astrocytes and have important roles in astrocyte function. Here, we review these recent developments and discuss their impact on our understanding of the pathophysiology of PD, and the implications that this might have for its treatment. Elsevier Applied Science Publishing 2017-06 /pmc/articles/PMC5462417/ /pubmed/28527591 http://dx.doi.org/10.1016/j.tins.2017.04.001 Text en © 2017 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Booth, Heather D.E. Hirst, Warren D. Wade-Martins, Richard The Role of Astrocyte Dysfunction in Parkinson’s Disease Pathogenesis |
title | The Role of Astrocyte Dysfunction in Parkinson’s Disease Pathogenesis |
title_full | The Role of Astrocyte Dysfunction in Parkinson’s Disease Pathogenesis |
title_fullStr | The Role of Astrocyte Dysfunction in Parkinson’s Disease Pathogenesis |
title_full_unstemmed | The Role of Astrocyte Dysfunction in Parkinson’s Disease Pathogenesis |
title_short | The Role of Astrocyte Dysfunction in Parkinson’s Disease Pathogenesis |
title_sort | role of astrocyte dysfunction in parkinson’s disease pathogenesis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5462417/ https://www.ncbi.nlm.nih.gov/pubmed/28527591 http://dx.doi.org/10.1016/j.tins.2017.04.001 |
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