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Occult hepatitis B virus infection in HIV positive patients at a tertiary healthcare unit in eastern India
Occult HBV infection (OBI), defined by the presence of HBV DNA in absence of hepatitis B surface antigen (HBsAg), is a significant concern in the HIV-infected population. Of 441 HIV+/HBsAg- patients analyzed, the overall prevalence of OBI was 6.3% (28/441). OBI was identified in 21 anti-HBc positive...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5462430/ https://www.ncbi.nlm.nih.gov/pubmed/28591184 http://dx.doi.org/10.1371/journal.pone.0179035 |
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author | Saha, Debraj Pal, Ananya Sarkar, Neelakshi Das, Dipanwita Blackard, Jason T. Guha, Subhasish Kamal Saha, Bibhuti Chakravarty, Runu |
author_facet | Saha, Debraj Pal, Ananya Sarkar, Neelakshi Das, Dipanwita Blackard, Jason T. Guha, Subhasish Kamal Saha, Bibhuti Chakravarty, Runu |
author_sort | Saha, Debraj |
collection | PubMed |
description | Occult HBV infection (OBI), defined by the presence of HBV DNA in absence of hepatitis B surface antigen (HBsAg), is a significant concern in the HIV-infected population. Of 441 HIV+/HBsAg- patients analyzed, the overall prevalence of OBI was 6.3% (28/441). OBI was identified in 21 anti-HBc positives (17.8%), as well as among those who lacked any HBV-specific serological markers (2.2%). Comparison with HIV/HBV co-infection revealed that the levels of CD4, ALT, and HBV DNA were significantly lower during occult infection. Discrete differences were also observed with respect to quasispecies divergence. Additionally, subgenotype D1 was most frequent in occult infection, while D2 was widespread during chronic infection. The majority (~90%) of occult D1 sequences had the sQ129R mutation in the surface gene. This study highlights several distinct features of OBI in India and underscores the need for additional HBV DNA screening in HIV-positive individuals. |
format | Online Article Text |
id | pubmed-5462430 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-54624302017-06-22 Occult hepatitis B virus infection in HIV positive patients at a tertiary healthcare unit in eastern India Saha, Debraj Pal, Ananya Sarkar, Neelakshi Das, Dipanwita Blackard, Jason T. Guha, Subhasish Kamal Saha, Bibhuti Chakravarty, Runu PLoS One Research Article Occult HBV infection (OBI), defined by the presence of HBV DNA in absence of hepatitis B surface antigen (HBsAg), is a significant concern in the HIV-infected population. Of 441 HIV+/HBsAg- patients analyzed, the overall prevalence of OBI was 6.3% (28/441). OBI was identified in 21 anti-HBc positives (17.8%), as well as among those who lacked any HBV-specific serological markers (2.2%). Comparison with HIV/HBV co-infection revealed that the levels of CD4, ALT, and HBV DNA were significantly lower during occult infection. Discrete differences were also observed with respect to quasispecies divergence. Additionally, subgenotype D1 was most frequent in occult infection, while D2 was widespread during chronic infection. The majority (~90%) of occult D1 sequences had the sQ129R mutation in the surface gene. This study highlights several distinct features of OBI in India and underscores the need for additional HBV DNA screening in HIV-positive individuals. Public Library of Science 2017-06-07 /pmc/articles/PMC5462430/ /pubmed/28591184 http://dx.doi.org/10.1371/journal.pone.0179035 Text en © 2017 Saha et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Saha, Debraj Pal, Ananya Sarkar, Neelakshi Das, Dipanwita Blackard, Jason T. Guha, Subhasish Kamal Saha, Bibhuti Chakravarty, Runu Occult hepatitis B virus infection in HIV positive patients at a tertiary healthcare unit in eastern India |
title | Occult hepatitis B virus infection in HIV positive patients at a tertiary healthcare unit in eastern India |
title_full | Occult hepatitis B virus infection in HIV positive patients at a tertiary healthcare unit in eastern India |
title_fullStr | Occult hepatitis B virus infection in HIV positive patients at a tertiary healthcare unit in eastern India |
title_full_unstemmed | Occult hepatitis B virus infection in HIV positive patients at a tertiary healthcare unit in eastern India |
title_short | Occult hepatitis B virus infection in HIV positive patients at a tertiary healthcare unit in eastern India |
title_sort | occult hepatitis b virus infection in hiv positive patients at a tertiary healthcare unit in eastern india |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5462430/ https://www.ncbi.nlm.nih.gov/pubmed/28591184 http://dx.doi.org/10.1371/journal.pone.0179035 |
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