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Occult hepatitis B virus infection in HIV positive patients at a tertiary healthcare unit in eastern India

Occult HBV infection (OBI), defined by the presence of HBV DNA in absence of hepatitis B surface antigen (HBsAg), is a significant concern in the HIV-infected population. Of 441 HIV+/HBsAg- patients analyzed, the overall prevalence of OBI was 6.3% (28/441). OBI was identified in 21 anti-HBc positive...

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Autores principales: Saha, Debraj, Pal, Ananya, Sarkar, Neelakshi, Das, Dipanwita, Blackard, Jason T., Guha, Subhasish Kamal, Saha, Bibhuti, Chakravarty, Runu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5462430/
https://www.ncbi.nlm.nih.gov/pubmed/28591184
http://dx.doi.org/10.1371/journal.pone.0179035
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author Saha, Debraj
Pal, Ananya
Sarkar, Neelakshi
Das, Dipanwita
Blackard, Jason T.
Guha, Subhasish Kamal
Saha, Bibhuti
Chakravarty, Runu
author_facet Saha, Debraj
Pal, Ananya
Sarkar, Neelakshi
Das, Dipanwita
Blackard, Jason T.
Guha, Subhasish Kamal
Saha, Bibhuti
Chakravarty, Runu
author_sort Saha, Debraj
collection PubMed
description Occult HBV infection (OBI), defined by the presence of HBV DNA in absence of hepatitis B surface antigen (HBsAg), is a significant concern in the HIV-infected population. Of 441 HIV+/HBsAg- patients analyzed, the overall prevalence of OBI was 6.3% (28/441). OBI was identified in 21 anti-HBc positives (17.8%), as well as among those who lacked any HBV-specific serological markers (2.2%). Comparison with HIV/HBV co-infection revealed that the levels of CD4, ALT, and HBV DNA were significantly lower during occult infection. Discrete differences were also observed with respect to quasispecies divergence. Additionally, subgenotype D1 was most frequent in occult infection, while D2 was widespread during chronic infection. The majority (~90%) of occult D1 sequences had the sQ129R mutation in the surface gene. This study highlights several distinct features of OBI in India and underscores the need for additional HBV DNA screening in HIV-positive individuals.
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spelling pubmed-54624302017-06-22 Occult hepatitis B virus infection in HIV positive patients at a tertiary healthcare unit in eastern India Saha, Debraj Pal, Ananya Sarkar, Neelakshi Das, Dipanwita Blackard, Jason T. Guha, Subhasish Kamal Saha, Bibhuti Chakravarty, Runu PLoS One Research Article Occult HBV infection (OBI), defined by the presence of HBV DNA in absence of hepatitis B surface antigen (HBsAg), is a significant concern in the HIV-infected population. Of 441 HIV+/HBsAg- patients analyzed, the overall prevalence of OBI was 6.3% (28/441). OBI was identified in 21 anti-HBc positives (17.8%), as well as among those who lacked any HBV-specific serological markers (2.2%). Comparison with HIV/HBV co-infection revealed that the levels of CD4, ALT, and HBV DNA were significantly lower during occult infection. Discrete differences were also observed with respect to quasispecies divergence. Additionally, subgenotype D1 was most frequent in occult infection, while D2 was widespread during chronic infection. The majority (~90%) of occult D1 sequences had the sQ129R mutation in the surface gene. This study highlights several distinct features of OBI in India and underscores the need for additional HBV DNA screening in HIV-positive individuals. Public Library of Science 2017-06-07 /pmc/articles/PMC5462430/ /pubmed/28591184 http://dx.doi.org/10.1371/journal.pone.0179035 Text en © 2017 Saha et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Saha, Debraj
Pal, Ananya
Sarkar, Neelakshi
Das, Dipanwita
Blackard, Jason T.
Guha, Subhasish Kamal
Saha, Bibhuti
Chakravarty, Runu
Occult hepatitis B virus infection in HIV positive patients at a tertiary healthcare unit in eastern India
title Occult hepatitis B virus infection in HIV positive patients at a tertiary healthcare unit in eastern India
title_full Occult hepatitis B virus infection in HIV positive patients at a tertiary healthcare unit in eastern India
title_fullStr Occult hepatitis B virus infection in HIV positive patients at a tertiary healthcare unit in eastern India
title_full_unstemmed Occult hepatitis B virus infection in HIV positive patients at a tertiary healthcare unit in eastern India
title_short Occult hepatitis B virus infection in HIV positive patients at a tertiary healthcare unit in eastern India
title_sort occult hepatitis b virus infection in hiv positive patients at a tertiary healthcare unit in eastern india
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5462430/
https://www.ncbi.nlm.nih.gov/pubmed/28591184
http://dx.doi.org/10.1371/journal.pone.0179035
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