Senescent cells: New target for an old treatment?

Many genotoxic chemotherapies have debilitating side effects and induce cellular senescence in normal tissues. Senescent cells acquire a pro-inflammatory phenotype which contributes to local and systemic inflammation. Eliminating senescent cells reduce several short- and long-term effects of the dru...

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Detalles Bibliográficos
Autor principal: Demaria, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5462517/
https://www.ncbi.nlm.nih.gov/pubmed/28616578
http://dx.doi.org/10.1080/23723556.2017.1299666
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author Demaria, Marco
author_facet Demaria, Marco
author_sort Demaria, Marco
collection PubMed
description Many genotoxic chemotherapies have debilitating side effects and induce cellular senescence in normal tissues. Senescent cells acquire a pro-inflammatory phenotype which contributes to local and systemic inflammation. Eliminating senescent cells reduce several short- and long-term effects of the drugs, providing a new target to reduce the toxicity of anticancer treatments.
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spelling pubmed-54625172018-04-03 Senescent cells: New target for an old treatment? Demaria, Marco Mol Cell Oncol Commentary Many genotoxic chemotherapies have debilitating side effects and induce cellular senescence in normal tissues. Senescent cells acquire a pro-inflammatory phenotype which contributes to local and systemic inflammation. Eliminating senescent cells reduce several short- and long-term effects of the drugs, providing a new target to reduce the toxicity of anticancer treatments. Taylor & Francis 2017-04-03 /pmc/articles/PMC5462517/ /pubmed/28616578 http://dx.doi.org/10.1080/23723556.2017.1299666 Text en © 2017 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Commentary
Demaria, Marco
Senescent cells: New target for an old treatment?
title Senescent cells: New target for an old treatment?
title_full Senescent cells: New target for an old treatment?
title_fullStr Senescent cells: New target for an old treatment?
title_full_unstemmed Senescent cells: New target for an old treatment?
title_short Senescent cells: New target for an old treatment?
title_sort senescent cells: new target for an old treatment?
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5462517/
https://www.ncbi.nlm.nih.gov/pubmed/28616578
http://dx.doi.org/10.1080/23723556.2017.1299666
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