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Crystal Structure of the Cul2-Rbx1-EloBC-VHL Ubiquitin Ligase Complex

Cullin RING E3 ubiquitin ligases (CRLs) function in the ubiquitin proteasome system to catalyze the transfer of ubiquitin from E2 conjugating enzymes to specific substrate proteins. CRLs are large dynamic complexes and attractive drug targets for the development of small-molecule inhibitors and chem...

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Detalles Bibliográficos
Autores principales:	Cardote, Teresa A.F., Gadd, Morgan S., Ciulli, Alessio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5462531/ https://www.ncbi.nlm.nih.gov/pubmed/28591624 http://dx.doi.org/10.1016/j.str.2017.04.009

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