Structural Studies of HHARI/UbcH7∼Ub Reveal Unique E2∼Ub Conformational Restriction by RBR RING1

RING-between-RING (RBR) E3s contain RING1 domains that are structurally similar yet mechanistically distinct from canonical RING domains. Both types of E3 bind E2∼ubiquitin (E2∼Ub) via their RINGs but canonical RING E3s promote closed E2∼Ub conformations required for direct Ub transfer from the E2 t...

Descripción completa

Detalles Bibliográficos
Autores principales: Dove, Katja K., Olszewski, Jennifer L., Martino, Luigi, Duda, David M., Wu, Xiaoli S., Miller, Darcie J., Reiter, Katherine H., Rittinger, Katrin, Schulman, Brenda A., Klevit, Rachel E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5462532/
https://www.ncbi.nlm.nih.gov/pubmed/28552575
http://dx.doi.org/10.1016/j.str.2017.04.013

Ejemplares similares

Ejemplares similares