The murine catecholamine methyltransferase mTOMT is essential for mechanotransduction by cochlear hair cells

Hair cells of the cochlea are mechanosensors for the perception of sound. Mutations in the LRTOMT gene, which encodes a protein with homology to the catecholamine methyltransferase COMT that is linked to schizophrenia, cause deafness. Here, we show that Tomt/Comt2, the murine ortholog of LRTOMT, has...

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Detalles Bibliográficos
Autores principales: Cunningham, Christopher L, Wu, Zizhen, Jafari, Aria, Zhao, Bo, Schrode, Kat, Harkins-Perry, Sarah, Lauer, Amanda, Müller, Ulrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5462538/
https://www.ncbi.nlm.nih.gov/pubmed/28504928
http://dx.doi.org/10.7554/eLife.24318

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