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Incorporation of Fluorescence Ceramide-Based HPLC Assay for Rapidly and Efficiently Assessing Glucosylceramide Synthase In Vivo

Glucosylceramide synthase (GCS) is a rate-limiting enzyme catalyzing ceramide glycosylation, thereby regulating cellular ceramide levels and the synthesis of glycosphingolipids (GSLs) in cellular membranes. Alterations of GCS not only affect membrane integrity, but also closely correlate with stem c...

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Detalles Bibliográficos
Autores principales:	Khiste, Sachin K., Hosain, Salman B., Dong, Yixuan, Uddin, Mohammad B., Roy, Kartik R., Hill, Ronald A., Liu, Zhijun, Liu, Yong-Yu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5462733/ https://www.ncbi.nlm.nih.gov/pubmed/28592871 http://dx.doi.org/10.1038/s41598-017-03320-9

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