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Pharmacological disruption of insulin-like growth factor 1 binding to IGF-binding proteins restores anabolic responses in human osteoarthritic chondrocytes

Insulin-like growth factor 1 (IGF-1) has poor anabolic efficacy in cartilage in osteoarthritis (OA), partly because of its sequestration by abnormally high levels of extracellular IGF-binding proteins (IGFBPs). We studied the effect of NBI-31772, a small molecule that inhibits the binding of IGF-1 t...

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Detalles Bibliográficos
Autores principales:	De Ceuninck, Frédéric, Caliez, Audrey, Dassencourt, Laurent, Anract, Philippe, Renard, Pierre
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2004
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC546277/ https://www.ncbi.nlm.nih.gov/pubmed/15380039 http://dx.doi.org/10.1186/ar1201

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