Imaging grading system for the diagnosis of dural ossification based on 102 segments of TOLF CT bone-window data

Thoracic ossification of the ligamentum flavum (TOLF) complicated with dural ossification (DO) is a severe clinical disease. The diagnosis of DO preoperatively remains challenging. The current study retrospectively analyzed imaging features of 102 segments with TOLF from 39 patients and proposed a g...

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Autores principales: Zhou, Sheng-yuan, Yuan, Bo, Chen, Xiong-sheng, Li, Xue-bin, Zhu, Wei, Jia, Lian-shun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5462817/
https://www.ncbi.nlm.nih.gov/pubmed/28592849
http://dx.doi.org/10.1038/s41598-017-03178-x
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author Zhou, Sheng-yuan
Yuan, Bo
Chen, Xiong-sheng
Li, Xue-bin
Zhu, Wei
Jia, Lian-shun
author_facet Zhou, Sheng-yuan
Yuan, Bo
Chen, Xiong-sheng
Li, Xue-bin
Zhu, Wei
Jia, Lian-shun
author_sort Zhou, Sheng-yuan
collection PubMed
description Thoracic ossification of the ligamentum flavum (TOLF) complicated with dural ossification (DO) is a severe clinical disease. The diagnosis of DO preoperatively remains challenging. The current study retrospectively analyzed imaging features of 102 segments with TOLF from 39 patients and proposed a grading system for evaluating DO risk. Logistic regression results showed that unilateral spinal canal occupational rate (UCOR), tram track signs, and C-signs were all risk factors for DO (odds ratios of 5.393, 19.734 and 72.594, respectively). In validation analyses for the TOLF-DO grading system, sensitivity was 76.0% (19/25), specificity was 91.0% (70/77), and Youden’s index was 0.66. Thus, implementation of the TOLF-DO grading system has the potential to improve the diagnosis of DO.
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spelling pubmed-54628172017-06-08 Imaging grading system for the diagnosis of dural ossification based on 102 segments of TOLF CT bone-window data Zhou, Sheng-yuan Yuan, Bo Chen, Xiong-sheng Li, Xue-bin Zhu, Wei Jia, Lian-shun Sci Rep Article Thoracic ossification of the ligamentum flavum (TOLF) complicated with dural ossification (DO) is a severe clinical disease. The diagnosis of DO preoperatively remains challenging. The current study retrospectively analyzed imaging features of 102 segments with TOLF from 39 patients and proposed a grading system for evaluating DO risk. Logistic regression results showed that unilateral spinal canal occupational rate (UCOR), tram track signs, and C-signs were all risk factors for DO (odds ratios of 5.393, 19.734 and 72.594, respectively). In validation analyses for the TOLF-DO grading system, sensitivity was 76.0% (19/25), specificity was 91.0% (70/77), and Youden’s index was 0.66. Thus, implementation of the TOLF-DO grading system has the potential to improve the diagnosis of DO. Nature Publishing Group UK 2017-06-07 /pmc/articles/PMC5462817/ /pubmed/28592849 http://dx.doi.org/10.1038/s41598-017-03178-x Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Zhou, Sheng-yuan
Yuan, Bo
Chen, Xiong-sheng
Li, Xue-bin
Zhu, Wei
Jia, Lian-shun
Imaging grading system for the diagnosis of dural ossification based on 102 segments of TOLF CT bone-window data
title Imaging grading system for the diagnosis of dural ossification based on 102 segments of TOLF CT bone-window data
title_full Imaging grading system for the diagnosis of dural ossification based on 102 segments of TOLF CT bone-window data
title_fullStr Imaging grading system for the diagnosis of dural ossification based on 102 segments of TOLF CT bone-window data
title_full_unstemmed Imaging grading system for the diagnosis of dural ossification based on 102 segments of TOLF CT bone-window data
title_short Imaging grading system for the diagnosis of dural ossification based on 102 segments of TOLF CT bone-window data
title_sort imaging grading system for the diagnosis of dural ossification based on 102 segments of tolf ct bone-window data
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5462817/
https://www.ncbi.nlm.nih.gov/pubmed/28592849
http://dx.doi.org/10.1038/s41598-017-03178-x
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