Inhibition of the Gab2/PI3K/mTOR signaling ameliorates myeloid malignancy caused by Ptpn11 (Shp2) gain-of-function mutations

Activating mutations, such as E76K and D61Y, in PTPN11 (SHP2), a protein tyrosine phosphatase implicated in multiple cell signaling processes, are associated with 35% of patients with juvenile myelomonocytic leukemia (JMML), an aggressive childhood myeloproliferative neoplasm (MPN). Effective therap...

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Detalles Bibliográficos
Autores principales: Liu, Wei, Yu, Wen-Mei, Zhang, Jing, Chan, Rebecca J., Loh, Mignon L., Zhang, Zheng, Bunting, Kevin D., Qu, Cheng-Kui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5462847/
https://www.ncbi.nlm.nih.gov/pubmed/27840422
http://dx.doi.org/10.1038/leu.2016.326

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5462847/
https://www.ncbi.nlm.nih.gov/pubmed/27840422
http://dx.doi.org/10.1038/leu.2016.326

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