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Elastin-Like Protein, with Statherin Derived Peptide, Controls Fluorapatite Formation and Morphology
The process of enamel biomineralization is multi-step, complex and mediated by organic molecules. The lack of cells in mature enamel leaves it unable to regenerate and hence novel ways of growing enamel-like structures are currently being investigated. Recently, elastin-like protein (ELP) with the a...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5462913/ https://www.ncbi.nlm.nih.gov/pubmed/28642715 http://dx.doi.org/10.3389/fphys.2017.00368 |
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author | Shuturminska, Kseniya Tarakina, Nadezda V. Azevedo, Helena S. Bushby, Andrew J. Mata, Alvaro Anderson, Paul Al-Jawad, Maisoon |
author_facet | Shuturminska, Kseniya Tarakina, Nadezda V. Azevedo, Helena S. Bushby, Andrew J. Mata, Alvaro Anderson, Paul Al-Jawad, Maisoon |
author_sort | Shuturminska, Kseniya |
collection | PubMed |
description | The process of enamel biomineralization is multi-step, complex and mediated by organic molecules. The lack of cells in mature enamel leaves it unable to regenerate and hence novel ways of growing enamel-like structures are currently being investigated. Recently, elastin-like protein (ELP) with the analog N-terminal sequence of statherin (STNA15-ELP) has been used to regenerate mineralized tissue. Here, the STNA15-ELP has been mineralized in constrained and unconstrained conditions in a fluoridated solution. We demonstrate that the control of STNA15-ELP delivery to the mineralizing solution can form layered ordered fluorapatite mineral, via a brushite precursor. We propose that the use of a constrained STNA15-ELP system can lead to the development of novel, bioinspired enamel therapeutics. |
format | Online Article Text |
id | pubmed-5462913 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-54629132017-06-22 Elastin-Like Protein, with Statherin Derived Peptide, Controls Fluorapatite Formation and Morphology Shuturminska, Kseniya Tarakina, Nadezda V. Azevedo, Helena S. Bushby, Andrew J. Mata, Alvaro Anderson, Paul Al-Jawad, Maisoon Front Physiol Physiology The process of enamel biomineralization is multi-step, complex and mediated by organic molecules. The lack of cells in mature enamel leaves it unable to regenerate and hence novel ways of growing enamel-like structures are currently being investigated. Recently, elastin-like protein (ELP) with the analog N-terminal sequence of statherin (STNA15-ELP) has been used to regenerate mineralized tissue. Here, the STNA15-ELP has been mineralized in constrained and unconstrained conditions in a fluoridated solution. We demonstrate that the control of STNA15-ELP delivery to the mineralizing solution can form layered ordered fluorapatite mineral, via a brushite precursor. We propose that the use of a constrained STNA15-ELP system can lead to the development of novel, bioinspired enamel therapeutics. Frontiers Media S.A. 2017-06-08 /pmc/articles/PMC5462913/ /pubmed/28642715 http://dx.doi.org/10.3389/fphys.2017.00368 Text en Copyright © 2017 Shuturminska, Tarakina, Azevedo, Bushby, Mata, Anderson and Al-Jawad. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Physiology Shuturminska, Kseniya Tarakina, Nadezda V. Azevedo, Helena S. Bushby, Andrew J. Mata, Alvaro Anderson, Paul Al-Jawad, Maisoon Elastin-Like Protein, with Statherin Derived Peptide, Controls Fluorapatite Formation and Morphology |
title | Elastin-Like Protein, with Statherin Derived Peptide, Controls Fluorapatite Formation and Morphology |
title_full | Elastin-Like Protein, with Statherin Derived Peptide, Controls Fluorapatite Formation and Morphology |
title_fullStr | Elastin-Like Protein, with Statherin Derived Peptide, Controls Fluorapatite Formation and Morphology |
title_full_unstemmed | Elastin-Like Protein, with Statherin Derived Peptide, Controls Fluorapatite Formation and Morphology |
title_short | Elastin-Like Protein, with Statherin Derived Peptide, Controls Fluorapatite Formation and Morphology |
title_sort | elastin-like protein, with statherin derived peptide, controls fluorapatite formation and morphology |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5462913/ https://www.ncbi.nlm.nih.gov/pubmed/28642715 http://dx.doi.org/10.3389/fphys.2017.00368 |
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