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Mutational Signatures Are Critical for Proper Estimation of Purifying Selection Pressures in Cancer Somatic Mutation Data When Using the dN/dS Metric

Large cancer genome sequencing initiatives have led to the identification of cancer driver genes based on signals of positive selection in somatic mutation data. Additionally, the identification of purifying (negative) selection has the potential to identify essential genes that may be of therapeuti...

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Detalles Bibliográficos
Autores principales:	Van den Eynden, Jimmy, Larsson, Erik
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2017
Materias:	Genetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5462936/ https://www.ncbi.nlm.nih.gov/pubmed/28642787 http://dx.doi.org/10.3389/fgene.2017.00074

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