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Cerebral Blood Flow and Amyloid-β Interact to Affect Memory Performance in Cognitively Normal Older Adults

Cerebral blood flow (CBF) alterations and amyloid-β (Aβ) accumulation have been independently linked to cognitive deficits in older adults at risk for dementia. Less is known about how CBF and Aβ may interact to affect cognition in cognitively normal older adults. Therefore, we examined potential st...

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Autores principales: Bangen, Katherine J., Clark, Alexandra L., Edmonds, Emily C., Evangelista, Nicole D., Werhane, Madeleine L., Thomas, Kelsey R., Locano, Lyzette E., Tran, My, Zlatar, Zvinka Z., Nation, Daniel A., Bondi, Mark W., Delano-Wood, Lisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5463038/
https://www.ncbi.nlm.nih.gov/pubmed/28642699
http://dx.doi.org/10.3389/fnagi.2017.00181
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author Bangen, Katherine J.
Clark, Alexandra L.
Edmonds, Emily C.
Evangelista, Nicole D.
Werhane, Madeleine L.
Thomas, Kelsey R.
Locano, Lyzette E.
Tran, My
Zlatar, Zvinka Z.
Nation, Daniel A.
Bondi, Mark W.
Delano-Wood, Lisa
author_facet Bangen, Katherine J.
Clark, Alexandra L.
Edmonds, Emily C.
Evangelista, Nicole D.
Werhane, Madeleine L.
Thomas, Kelsey R.
Locano, Lyzette E.
Tran, My
Zlatar, Zvinka Z.
Nation, Daniel A.
Bondi, Mark W.
Delano-Wood, Lisa
author_sort Bangen, Katherine J.
collection PubMed
description Cerebral blood flow (CBF) alterations and amyloid-β (Aβ) accumulation have been independently linked to cognitive deficits in older adults at risk for dementia. Less is known about how CBF and Aβ may interact to affect cognition in cognitively normal older adults. Therefore, we examined potential statistical interactions between CBF and Aβ status in regions typically affected in Alzheimer’s disease (AD) within a sample of older adults from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) study. Sixty-two cognitively normal participants (mean age = 72 years) underwent neuroimaging and memory testing. Arterial spin labeling magnetic resonance imaging was used to quantify CBF and florbetapir PET amyloid imaging was used to measure Aβ deposition. Aβ status (i.e., positivity versus negativity) was determined based on established cutoffs (Landau et al., 2013). The Rey Auditory Verbal Learning Test was used to assess memory. Linear regression models adjusted for age, education, and sex, demonstrated significant interactions between CBF and Aβ status on memory performance. Among Aβ positive older adults, there were significant negative associations between higher CBF in hippocampus, posterior cingulate, and precuneus and poorer memory performance. In contrast, among Aβ negative older adults, there were no significant associations between CBF and cognition. Our findings extend previous CBF studies of dementia risk by reporting interactions between Aβ status and CBF on memory performance in a sample of well-characterized, cognitively normal older adults. Results suggest that differential CBF-cognition associations can be identified in healthy, asymptomatic Aβ positive older adults relative to Aβ negative individuals. Associations between higherCBF and poorer memory among Aβ positive older adults may reflect a cellular and/or vascular compensatory response to pathologic processes whereby higher CBF is needed to maintain normal memory abilities. Findings indicate that CBF and its associations with cognition may have utility as a reliable marker of brain function early in the AD process when interventions are likely to be beneficial.
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spelling pubmed-54630382017-06-22 Cerebral Blood Flow and Amyloid-β Interact to Affect Memory Performance in Cognitively Normal Older Adults Bangen, Katherine J. Clark, Alexandra L. Edmonds, Emily C. Evangelista, Nicole D. Werhane, Madeleine L. Thomas, Kelsey R. Locano, Lyzette E. Tran, My Zlatar, Zvinka Z. Nation, Daniel A. Bondi, Mark W. Delano-Wood, Lisa Front Aging Neurosci Neuroscience Cerebral blood flow (CBF) alterations and amyloid-β (Aβ) accumulation have been independently linked to cognitive deficits in older adults at risk for dementia. Less is known about how CBF and Aβ may interact to affect cognition in cognitively normal older adults. Therefore, we examined potential statistical interactions between CBF and Aβ status in regions typically affected in Alzheimer’s disease (AD) within a sample of older adults from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) study. Sixty-two cognitively normal participants (mean age = 72 years) underwent neuroimaging and memory testing. Arterial spin labeling magnetic resonance imaging was used to quantify CBF and florbetapir PET amyloid imaging was used to measure Aβ deposition. Aβ status (i.e., positivity versus negativity) was determined based on established cutoffs (Landau et al., 2013). The Rey Auditory Verbal Learning Test was used to assess memory. Linear regression models adjusted for age, education, and sex, demonstrated significant interactions between CBF and Aβ status on memory performance. Among Aβ positive older adults, there were significant negative associations between higher CBF in hippocampus, posterior cingulate, and precuneus and poorer memory performance. In contrast, among Aβ negative older adults, there were no significant associations between CBF and cognition. Our findings extend previous CBF studies of dementia risk by reporting interactions between Aβ status and CBF on memory performance in a sample of well-characterized, cognitively normal older adults. Results suggest that differential CBF-cognition associations can be identified in healthy, asymptomatic Aβ positive older adults relative to Aβ negative individuals. Associations between higherCBF and poorer memory among Aβ positive older adults may reflect a cellular and/or vascular compensatory response to pathologic processes whereby higher CBF is needed to maintain normal memory abilities. Findings indicate that CBF and its associations with cognition may have utility as a reliable marker of brain function early in the AD process when interventions are likely to be beneficial. Frontiers Media S.A. 2017-06-08 /pmc/articles/PMC5463038/ /pubmed/28642699 http://dx.doi.org/10.3389/fnagi.2017.00181 Text en Copyright © 2017 Bangen, Clark, Edmonds, Evangelista, Werhane, Thomas, Locano, Tran, Zlatar, Nation, Bondi, and Delano-Wood for the Alzheimer’s Disease Neuroimaging Initiative. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Bangen, Katherine J.
Clark, Alexandra L.
Edmonds, Emily C.
Evangelista, Nicole D.
Werhane, Madeleine L.
Thomas, Kelsey R.
Locano, Lyzette E.
Tran, My
Zlatar, Zvinka Z.
Nation, Daniel A.
Bondi, Mark W.
Delano-Wood, Lisa
Cerebral Blood Flow and Amyloid-β Interact to Affect Memory Performance in Cognitively Normal Older Adults
title Cerebral Blood Flow and Amyloid-β Interact to Affect Memory Performance in Cognitively Normal Older Adults
title_full Cerebral Blood Flow and Amyloid-β Interact to Affect Memory Performance in Cognitively Normal Older Adults
title_fullStr Cerebral Blood Flow and Amyloid-β Interact to Affect Memory Performance in Cognitively Normal Older Adults
title_full_unstemmed Cerebral Blood Flow and Amyloid-β Interact to Affect Memory Performance in Cognitively Normal Older Adults
title_short Cerebral Blood Flow and Amyloid-β Interact to Affect Memory Performance in Cognitively Normal Older Adults
title_sort cerebral blood flow and amyloid-β interact to affect memory performance in cognitively normal older adults
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5463038/
https://www.ncbi.nlm.nih.gov/pubmed/28642699
http://dx.doi.org/10.3389/fnagi.2017.00181
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