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Leptin/Adiponectin Ratios Using Either Total Or High-Molecular-Weight Adiponectin as Biomarkers of Systemic Insulin Sensitivity in Normoglycemic Women

Plasma leptin/adiponectin ratio (LAR) is negatively associated with insulin sensitivity indexes. High-molecular-weight adiponectin (HMWA) was proposed as the most biologically active form of this insulin-sensitizing adipokine. There are no studies assessing the relative merits of leptin/HMWA ratio o...

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Autores principales: Bravo, Carolina, Cataldo, Luis Rodrigo, Galgani, José, Parada, Javier, Santos, José Luis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5463152/
https://www.ncbi.nlm.nih.gov/pubmed/28626772
http://dx.doi.org/10.1155/2017/9031079
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author Bravo, Carolina
Cataldo, Luis Rodrigo
Galgani, José
Parada, Javier
Santos, José Luis
author_facet Bravo, Carolina
Cataldo, Luis Rodrigo
Galgani, José
Parada, Javier
Santos, José Luis
author_sort Bravo, Carolina
collection PubMed
description Plasma leptin/adiponectin ratio (LAR) is negatively associated with insulin sensitivity indexes. High-molecular-weight adiponectin (HMWA) was proposed as the most biologically active form of this insulin-sensitizing adipokine. There are no studies assessing the relative merits of leptin/HMWA ratio over LAR as a biomarker of systemic insulin sensitivity. A standard 2-hour oral glucose tolerance test (OGTT; 75 g of glucose) and a short minimal-model intravenous glucose tolerance test (IVGTT; 0.3 g/kg body weight) were performed in 58 Chilean normoglycemic women (age: 27 ± 6.3 years, BMI 23.6 ± 3.2 kg/m(2)). LAR was negatively associated with HOMA-S (r = −0.49; p < 0.0001), Matsuda-ISICOMP (r = −0.54; p < 0.0001), and the calculated sensitivity index (CSi) derived from IVGTT (r = −0.38; p = 0.007). In comparison to LAR, leptin/HMWA ratio did not increase neither the linear fit (r(2)) nor the magnitude of association with insulin sensitivity indexes (slope of multiple linear regression). The discriminatory capacity of both ratios to classify insulin-resistant versus insulin-sensitive subjects was similar for HOMA-S (p = 0.84), Matsuda-ISICOMP (p = 0.43), or CSi (p = 0.50). In conclusion, LAR showed consistent negative associations with different systemic insulin sensitivity indexes. The use of HMWA to generate leptin/HMWA ratio did not show any advantage over LAR as a biomarker of systemic insulin sensitivity in normoglycemic women.
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spelling pubmed-54631522017-06-18 Leptin/Adiponectin Ratios Using Either Total Or High-Molecular-Weight Adiponectin as Biomarkers of Systemic Insulin Sensitivity in Normoglycemic Women Bravo, Carolina Cataldo, Luis Rodrigo Galgani, José Parada, Javier Santos, José Luis J Diabetes Res Research Article Plasma leptin/adiponectin ratio (LAR) is negatively associated with insulin sensitivity indexes. High-molecular-weight adiponectin (HMWA) was proposed as the most biologically active form of this insulin-sensitizing adipokine. There are no studies assessing the relative merits of leptin/HMWA ratio over LAR as a biomarker of systemic insulin sensitivity. A standard 2-hour oral glucose tolerance test (OGTT; 75 g of glucose) and a short minimal-model intravenous glucose tolerance test (IVGTT; 0.3 g/kg body weight) were performed in 58 Chilean normoglycemic women (age: 27 ± 6.3 years, BMI 23.6 ± 3.2 kg/m(2)). LAR was negatively associated with HOMA-S (r = −0.49; p < 0.0001), Matsuda-ISICOMP (r = −0.54; p < 0.0001), and the calculated sensitivity index (CSi) derived from IVGTT (r = −0.38; p = 0.007). In comparison to LAR, leptin/HMWA ratio did not increase neither the linear fit (r(2)) nor the magnitude of association with insulin sensitivity indexes (slope of multiple linear regression). The discriminatory capacity of both ratios to classify insulin-resistant versus insulin-sensitive subjects was similar for HOMA-S (p = 0.84), Matsuda-ISICOMP (p = 0.43), or CSi (p = 0.50). In conclusion, LAR showed consistent negative associations with different systemic insulin sensitivity indexes. The use of HMWA to generate leptin/HMWA ratio did not show any advantage over LAR as a biomarker of systemic insulin sensitivity in normoglycemic women. Hindawi 2017 2017-05-25 /pmc/articles/PMC5463152/ /pubmed/28626772 http://dx.doi.org/10.1155/2017/9031079 Text en Copyright © 2017 Carolina Bravo et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Bravo, Carolina
Cataldo, Luis Rodrigo
Galgani, José
Parada, Javier
Santos, José Luis
Leptin/Adiponectin Ratios Using Either Total Or High-Molecular-Weight Adiponectin as Biomarkers of Systemic Insulin Sensitivity in Normoglycemic Women
title Leptin/Adiponectin Ratios Using Either Total Or High-Molecular-Weight Adiponectin as Biomarkers of Systemic Insulin Sensitivity in Normoglycemic Women
title_full Leptin/Adiponectin Ratios Using Either Total Or High-Molecular-Weight Adiponectin as Biomarkers of Systemic Insulin Sensitivity in Normoglycemic Women
title_fullStr Leptin/Adiponectin Ratios Using Either Total Or High-Molecular-Weight Adiponectin as Biomarkers of Systemic Insulin Sensitivity in Normoglycemic Women
title_full_unstemmed Leptin/Adiponectin Ratios Using Either Total Or High-Molecular-Weight Adiponectin as Biomarkers of Systemic Insulin Sensitivity in Normoglycemic Women
title_short Leptin/Adiponectin Ratios Using Either Total Or High-Molecular-Weight Adiponectin as Biomarkers of Systemic Insulin Sensitivity in Normoglycemic Women
title_sort leptin/adiponectin ratios using either total or high-molecular-weight adiponectin as biomarkers of systemic insulin sensitivity in normoglycemic women
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5463152/
https://www.ncbi.nlm.nih.gov/pubmed/28626772
http://dx.doi.org/10.1155/2017/9031079
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