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CD146 Promoter Polymorphism (rs3923594) Is Associated with Recurrence of Clear Cell Renal Cell Carcinoma in Chinese Population

INTRODUCTION: CD146 is a membrane signal receptor in tumor-induced angiogenesis. However, limited studies have focused on the CD146 promoter polymorphisms in clear cell renal cell carcinoma (ccRCC). PURPOSE: The purpose of this study was to investigate the association between polymorphisms located i...

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Autores principales: Feng, Gang, Huang, Hou-Bao, Ye, Xiao-Bing, Zhang, Peng, Huang, Jian-Jun, Huang, Li-Zhu, Cheng, Long, Pu, Chun, Li, Guorong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5463157/
https://www.ncbi.nlm.nih.gov/pubmed/28626293
http://dx.doi.org/10.1155/2017/2543059
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author Feng, Gang
Huang, Hou-Bao
Ye, Xiao-Bing
Zhang, Peng
Huang, Jian-Jun
Huang, Li-Zhu
Cheng, Long
Pu, Chun
Li, Guorong
author_facet Feng, Gang
Huang, Hou-Bao
Ye, Xiao-Bing
Zhang, Peng
Huang, Jian-Jun
Huang, Li-Zhu
Cheng, Long
Pu, Chun
Li, Guorong
author_sort Feng, Gang
collection PubMed
description INTRODUCTION: CD146 is a membrane signal receptor in tumor-induced angiogenesis. However, limited studies have focused on the CD146 promoter polymorphisms in clear cell renal cell carcinoma (ccRCC). PURPOSE: The purpose of this study was to investigate the association between polymorphisms located in the promoter region of the CD146 gene and characteristics of ccRCC in Chinese population. The association between the CD146 promoter polymorphisms and CD146 expression was also investigated in ccRCC. MATERIALS AND METHODS: A total of 600 samples including 300 ccRCC patients and 300 healthy controls were collected for analysis of the CD146 promoter polymorphisms by direct sequence. The CD146 expressions were measured by qRT-PCR. RESULTS: We had not found any significant differences in genotypic and allelic frequencies of CD146 promoter polymorphisms between ccRCC patients and controls. The rs3923594 was associated with stage and metastasis (300 cases) and recurrence (263 cases) of ccRCC in Chinese population. A significant association was also observed between the rs3923594 and CD146 expression (227 cases) in ccRCC. CONCLUSIONS: CD146 promoter polymorphisms were not associated with the risk of ccRCC in Chinese population. The rs3923594 was an independent predictor of recurrence in Chinese patients with localized ccRCC.
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spelling pubmed-54631572017-06-18 CD146 Promoter Polymorphism (rs3923594) Is Associated with Recurrence of Clear Cell Renal Cell Carcinoma in Chinese Population Feng, Gang Huang, Hou-Bao Ye, Xiao-Bing Zhang, Peng Huang, Jian-Jun Huang, Li-Zhu Cheng, Long Pu, Chun Li, Guorong Dis Markers Research Article INTRODUCTION: CD146 is a membrane signal receptor in tumor-induced angiogenesis. However, limited studies have focused on the CD146 promoter polymorphisms in clear cell renal cell carcinoma (ccRCC). PURPOSE: The purpose of this study was to investigate the association between polymorphisms located in the promoter region of the CD146 gene and characteristics of ccRCC in Chinese population. The association between the CD146 promoter polymorphisms and CD146 expression was also investigated in ccRCC. MATERIALS AND METHODS: A total of 600 samples including 300 ccRCC patients and 300 healthy controls were collected for analysis of the CD146 promoter polymorphisms by direct sequence. The CD146 expressions were measured by qRT-PCR. RESULTS: We had not found any significant differences in genotypic and allelic frequencies of CD146 promoter polymorphisms between ccRCC patients and controls. The rs3923594 was associated with stage and metastasis (300 cases) and recurrence (263 cases) of ccRCC in Chinese population. A significant association was also observed between the rs3923594 and CD146 expression (227 cases) in ccRCC. CONCLUSIONS: CD146 promoter polymorphisms were not associated with the risk of ccRCC in Chinese population. The rs3923594 was an independent predictor of recurrence in Chinese patients with localized ccRCC. Hindawi 2017 2017-05-24 /pmc/articles/PMC5463157/ /pubmed/28626293 http://dx.doi.org/10.1155/2017/2543059 Text en Copyright © 2017 Gang Feng et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Feng, Gang
Huang, Hou-Bao
Ye, Xiao-Bing
Zhang, Peng
Huang, Jian-Jun
Huang, Li-Zhu
Cheng, Long
Pu, Chun
Li, Guorong
CD146 Promoter Polymorphism (rs3923594) Is Associated with Recurrence of Clear Cell Renal Cell Carcinoma in Chinese Population
title CD146 Promoter Polymorphism (rs3923594) Is Associated with Recurrence of Clear Cell Renal Cell Carcinoma in Chinese Population
title_full CD146 Promoter Polymorphism (rs3923594) Is Associated with Recurrence of Clear Cell Renal Cell Carcinoma in Chinese Population
title_fullStr CD146 Promoter Polymorphism (rs3923594) Is Associated with Recurrence of Clear Cell Renal Cell Carcinoma in Chinese Population
title_full_unstemmed CD146 Promoter Polymorphism (rs3923594) Is Associated with Recurrence of Clear Cell Renal Cell Carcinoma in Chinese Population
title_short CD146 Promoter Polymorphism (rs3923594) Is Associated with Recurrence of Clear Cell Renal Cell Carcinoma in Chinese Population
title_sort cd146 promoter polymorphism (rs3923594) is associated with recurrence of clear cell renal cell carcinoma in chinese population
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5463157/
https://www.ncbi.nlm.nih.gov/pubmed/28626293
http://dx.doi.org/10.1155/2017/2543059
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