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NADPH Oxidases: Insights into Selected Functions and Mechanisms of Action in Cancer and Stem Cells

NADPH oxidases (NOX) are reactive oxygen species- (ROS-) generating enzymes regulating numerous redox-dependent signaling pathways. NOX are important regulators of cell differentiation, growth, and proliferation and of mechanisms, important for a wide range of processes from embryonic development, t...

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Autores principales: Skonieczna, Magdalena, Hejmo, Tomasz, Poterala-Hejmo, Aleksandra, Cieslar-Pobuda, Artur, Buldak, Rafal J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5463201/
https://www.ncbi.nlm.nih.gov/pubmed/28626501
http://dx.doi.org/10.1155/2017/9420539
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author Skonieczna, Magdalena
Hejmo, Tomasz
Poterala-Hejmo, Aleksandra
Cieslar-Pobuda, Artur
Buldak, Rafal J.
author_facet Skonieczna, Magdalena
Hejmo, Tomasz
Poterala-Hejmo, Aleksandra
Cieslar-Pobuda, Artur
Buldak, Rafal J.
author_sort Skonieczna, Magdalena
collection PubMed
description NADPH oxidases (NOX) are reactive oxygen species- (ROS-) generating enzymes regulating numerous redox-dependent signaling pathways. NOX are important regulators of cell differentiation, growth, and proliferation and of mechanisms, important for a wide range of processes from embryonic development, through tissue regeneration to the development and spread of cancer. In this review, we discuss the roles of NOX and NOX-derived ROS in the functioning of stem cells and cancer stem cells and in selected aspects of cancer cell physiology. Understanding the functions and complex activities of NOX is important for the application of stem cells in tissue engineering, regenerative medicine, and development of new therapies toward invasive forms of cancers.
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spelling pubmed-54632012017-06-18 NADPH Oxidases: Insights into Selected Functions and Mechanisms of Action in Cancer and Stem Cells Skonieczna, Magdalena Hejmo, Tomasz Poterala-Hejmo, Aleksandra Cieslar-Pobuda, Artur Buldak, Rafal J. Oxid Med Cell Longev Review Article NADPH oxidases (NOX) are reactive oxygen species- (ROS-) generating enzymes regulating numerous redox-dependent signaling pathways. NOX are important regulators of cell differentiation, growth, and proliferation and of mechanisms, important for a wide range of processes from embryonic development, through tissue regeneration to the development and spread of cancer. In this review, we discuss the roles of NOX and NOX-derived ROS in the functioning of stem cells and cancer stem cells and in selected aspects of cancer cell physiology. Understanding the functions and complex activities of NOX is important for the application of stem cells in tissue engineering, regenerative medicine, and development of new therapies toward invasive forms of cancers. Hindawi 2017 2017-05-23 /pmc/articles/PMC5463201/ /pubmed/28626501 http://dx.doi.org/10.1155/2017/9420539 Text en Copyright © 2017 Magdalena Skonieczna et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Skonieczna, Magdalena
Hejmo, Tomasz
Poterala-Hejmo, Aleksandra
Cieslar-Pobuda, Artur
Buldak, Rafal J.
NADPH Oxidases: Insights into Selected Functions and Mechanisms of Action in Cancer and Stem Cells
title NADPH Oxidases: Insights into Selected Functions and Mechanisms of Action in Cancer and Stem Cells
title_full NADPH Oxidases: Insights into Selected Functions and Mechanisms of Action in Cancer and Stem Cells
title_fullStr NADPH Oxidases: Insights into Selected Functions and Mechanisms of Action in Cancer and Stem Cells
title_full_unstemmed NADPH Oxidases: Insights into Selected Functions and Mechanisms of Action in Cancer and Stem Cells
title_short NADPH Oxidases: Insights into Selected Functions and Mechanisms of Action in Cancer and Stem Cells
title_sort nadph oxidases: insights into selected functions and mechanisms of action in cancer and stem cells
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5463201/
https://www.ncbi.nlm.nih.gov/pubmed/28626501
http://dx.doi.org/10.1155/2017/9420539
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