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A reappraised meta-analysis of the genetic association between vitamin D receptor BsmI (rs1544410) polymorphism and pulmonary tuberculosis risk

BsmI (rs1544410) polymorphism located in intron 8 at the 3′-end of the vitamin D receptor (VDR) gene is known to be involved in the regulation of mRNA stability. Many studies evaluated the possible correlation between VDR BsmI polymorphism and the risk of pulmonary tuberculosis (PTB), and reported c...

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Autores principales: Areeshi, Mohammed Y., Mandal, Raju K., Dar, Sajad A., Alshahrani, Abdulrahman M., Ahmad, Aqeel, Jawed, Arshad, Wahid, Mohd, Lohani, Mohtashim, Panda, Aditya K., Haque, Shafiul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5463263/
https://www.ncbi.nlm.nih.gov/pubmed/28533426
http://dx.doi.org/10.1042/BSR20170247
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author Areeshi, Mohammed Y.
Mandal, Raju K.
Dar, Sajad A.
Alshahrani, Abdulrahman M.
Ahmad, Aqeel
Jawed, Arshad
Wahid, Mohd
Lohani, Mohtashim
Panda, Aditya K.
Haque, Shafiul
author_facet Areeshi, Mohammed Y.
Mandal, Raju K.
Dar, Sajad A.
Alshahrani, Abdulrahman M.
Ahmad, Aqeel
Jawed, Arshad
Wahid, Mohd
Lohani, Mohtashim
Panda, Aditya K.
Haque, Shafiul
author_sort Areeshi, Mohammed Y.
collection PubMed
description BsmI (rs1544410) polymorphism located in intron 8 at the 3′-end of the vitamin D receptor (VDR) gene is known to be involved in the regulation of mRNA stability. Many studies evaluated the possible correlation between VDR BsmI polymorphism and the risk of pulmonary tuberculosis (PTB), and reported conflicting results. In the present study, an updated meta-analysis was performed to evaluate the above-said association. PubMed, Embase, and Google Scholar web-databases were searched for the relevant studies and a meta-analysis was performed by calculating pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) for all the genetic models. A total of 19 studies comprising 3644 controls and 2635 cases were included in the present study. Overall no association of PTB in allelic contrast (b compared with B: P=0.285; OR =0.909, 95% CI =0.762–1.083), homozygous (bb compared with BB: P=0.881; OR =0.975, 95% CI =0.700–1.359), heterozygous (bB compared with BB: P=0.834; OR =1.017, 95% CI =0.872–1.185), dominant (bb compared with BB + Bb: P=0.451; OR =0.954, 95% CI =0.843–1.079) and recessive (bb + Bb compared with BB: P=0.983; OR =1.002, 95% CI =0.868–1.156) genetic models in comparison with wild-type allele and genotype BB were observed. However, variant allele (b compared with B: P=0.001; OR =2.289, 95% CI =1.661–3.154) showed increased risk of PTB in Asians. In conclusion, VDR BsmI polymorphism is not a risk factor for PTB in overall population. However, this polymorphism may be interrelated to an increased risk of PTB amongst Asians.
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spelling pubmed-54632632017-06-13 A reappraised meta-analysis of the genetic association between vitamin D receptor BsmI (rs1544410) polymorphism and pulmonary tuberculosis risk Areeshi, Mohammed Y. Mandal, Raju K. Dar, Sajad A. Alshahrani, Abdulrahman M. Ahmad, Aqeel Jawed, Arshad Wahid, Mohd Lohani, Mohtashim Panda, Aditya K. Haque, Shafiul Biosci Rep Research Articles BsmI (rs1544410) polymorphism located in intron 8 at the 3′-end of the vitamin D receptor (VDR) gene is known to be involved in the regulation of mRNA stability. Many studies evaluated the possible correlation between VDR BsmI polymorphism and the risk of pulmonary tuberculosis (PTB), and reported conflicting results. In the present study, an updated meta-analysis was performed to evaluate the above-said association. PubMed, Embase, and Google Scholar web-databases were searched for the relevant studies and a meta-analysis was performed by calculating pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) for all the genetic models. A total of 19 studies comprising 3644 controls and 2635 cases were included in the present study. Overall no association of PTB in allelic contrast (b compared with B: P=0.285; OR =0.909, 95% CI =0.762–1.083), homozygous (bb compared with BB: P=0.881; OR =0.975, 95% CI =0.700–1.359), heterozygous (bB compared with BB: P=0.834; OR =1.017, 95% CI =0.872–1.185), dominant (bb compared with BB + Bb: P=0.451; OR =0.954, 95% CI =0.843–1.079) and recessive (bb + Bb compared with BB: P=0.983; OR =1.002, 95% CI =0.868–1.156) genetic models in comparison with wild-type allele and genotype BB were observed. However, variant allele (b compared with B: P=0.001; OR =2.289, 95% CI =1.661–3.154) showed increased risk of PTB in Asians. In conclusion, VDR BsmI polymorphism is not a risk factor for PTB in overall population. However, this polymorphism may be interrelated to an increased risk of PTB amongst Asians. Portland Press Ltd. 2017-06-07 /pmc/articles/PMC5463263/ /pubmed/28533426 http://dx.doi.org/10.1042/BSR20170247 Text en © 2017 The Author(s). http://creativecommons.org/licenses/by/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (http://creativecommons.org/licenses/by/4.0/) .
spellingShingle Research Articles
Areeshi, Mohammed Y.
Mandal, Raju K.
Dar, Sajad A.
Alshahrani, Abdulrahman M.
Ahmad, Aqeel
Jawed, Arshad
Wahid, Mohd
Lohani, Mohtashim
Panda, Aditya K.
Haque, Shafiul
A reappraised meta-analysis of the genetic association between vitamin D receptor BsmI (rs1544410) polymorphism and pulmonary tuberculosis risk
title A reappraised meta-analysis of the genetic association between vitamin D receptor BsmI (rs1544410) polymorphism and pulmonary tuberculosis risk
title_full A reappraised meta-analysis of the genetic association between vitamin D receptor BsmI (rs1544410) polymorphism and pulmonary tuberculosis risk
title_fullStr A reappraised meta-analysis of the genetic association between vitamin D receptor BsmI (rs1544410) polymorphism and pulmonary tuberculosis risk
title_full_unstemmed A reappraised meta-analysis of the genetic association between vitamin D receptor BsmI (rs1544410) polymorphism and pulmonary tuberculosis risk
title_short A reappraised meta-analysis of the genetic association between vitamin D receptor BsmI (rs1544410) polymorphism and pulmonary tuberculosis risk
title_sort reappraised meta-analysis of the genetic association between vitamin d receptor bsmi (rs1544410) polymorphism and pulmonary tuberculosis risk
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5463263/
https://www.ncbi.nlm.nih.gov/pubmed/28533426
http://dx.doi.org/10.1042/BSR20170247
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