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Menarcheal Age and Risk of Type 2 Diabetes: A Community-Based Cohort Study

OBJECTIVE: It has been reported that early menarche is associated with higher risk for type 2 diabetes. We aimed to explore the association between age at menarche and risk of type 2 diabetes in a population-based cohort study. METHODS: For the purpose of the present study, 5191 subjects of reproduc...

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Autores principales: Farahmand, Maryam, Tehrani, Fahimeh Ramezani, Dovom, Marzieh Rostami, Azizi, Fereidoun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Galenos Publishing 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5463289/
https://www.ncbi.nlm.nih.gov/pubmed/27840328
http://dx.doi.org/10.4274/jcrpe.3370
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author Farahmand, Maryam
Tehrani, Fahimeh Ramezani
Dovom, Marzieh Rostami
Azizi, Fereidoun
author_facet Farahmand, Maryam
Tehrani, Fahimeh Ramezani
Dovom, Marzieh Rostami
Azizi, Fereidoun
author_sort Farahmand, Maryam
collection PubMed
description OBJECTIVE: It has been reported that early menarche is associated with higher risk for type 2 diabetes. We aimed to explore the association between age at menarche and risk of type 2 diabetes in a population-based cohort study. METHODS: For the purpose of the present study, 5191 subjects of reproductive age who were participants of the Tehran Lipid and Glucose Study and also met the eligibility criteria were selected. Demographic, lifestyle, reproductive, and anthropometric data as well as risk factors for metabolic diseases were collected. Menarcheal age was categorized into five categories, as <11 years, 11-12 years, 13-14 years, 15-16 years, and >17 years. Diabetes and pre-diabetes were defined according to the American Diabetes Association criteria. Logistic regression analysis was used to assess the risk of the menarcheal age group for type 2 diabetes and pre-diabetes. RESULTS: Of 5625 participants, 673 women had pre-diabetes and 187 had diabetes. Early menarche was associated with higher risk of diabetes and pre-diabetes, compared to the reference group (13-14 years), (OR=3.55, 95% CI: 1.6-7.8 and OR=2.55, 95% CI:1.4-4.8, respectively), an association which remained after further adjustment for potential confounders including family history of diabetes, parity, education, age, body mass index, waist circumference, smoking history, physical activity, and duration of oral contraceptives use. CONCLUSION: Results showed early menarche to be a potential risk factor for type 2 diabetes and pre-diabetes.
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spelling pubmed-54632892017-06-15 Menarcheal Age and Risk of Type 2 Diabetes: A Community-Based Cohort Study Farahmand, Maryam Tehrani, Fahimeh Ramezani Dovom, Marzieh Rostami Azizi, Fereidoun J Clin Res Pediatr Endocrinol Original Article OBJECTIVE: It has been reported that early menarche is associated with higher risk for type 2 diabetes. We aimed to explore the association between age at menarche and risk of type 2 diabetes in a population-based cohort study. METHODS: For the purpose of the present study, 5191 subjects of reproductive age who were participants of the Tehran Lipid and Glucose Study and also met the eligibility criteria were selected. Demographic, lifestyle, reproductive, and anthropometric data as well as risk factors for metabolic diseases were collected. Menarcheal age was categorized into five categories, as <11 years, 11-12 years, 13-14 years, 15-16 years, and >17 years. Diabetes and pre-diabetes were defined according to the American Diabetes Association criteria. Logistic regression analysis was used to assess the risk of the menarcheal age group for type 2 diabetes and pre-diabetes. RESULTS: Of 5625 participants, 673 women had pre-diabetes and 187 had diabetes. Early menarche was associated with higher risk of diabetes and pre-diabetes, compared to the reference group (13-14 years), (OR=3.55, 95% CI: 1.6-7.8 and OR=2.55, 95% CI:1.4-4.8, respectively), an association which remained after further adjustment for potential confounders including family history of diabetes, parity, education, age, body mass index, waist circumference, smoking history, physical activity, and duration of oral contraceptives use. CONCLUSION: Results showed early menarche to be a potential risk factor for type 2 diabetes and pre-diabetes. Galenos Publishing 2017-06 2017-06-01 /pmc/articles/PMC5463289/ /pubmed/27840328 http://dx.doi.org/10.4274/jcrpe.3370 Text en © Journal of Clinical Research in Pediatric Endocrinology, Published by Galenos Publishing. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Farahmand, Maryam
Tehrani, Fahimeh Ramezani
Dovom, Marzieh Rostami
Azizi, Fereidoun
Menarcheal Age and Risk of Type 2 Diabetes: A Community-Based Cohort Study
title Menarcheal Age and Risk of Type 2 Diabetes: A Community-Based Cohort Study
title_full Menarcheal Age and Risk of Type 2 Diabetes: A Community-Based Cohort Study
title_fullStr Menarcheal Age and Risk of Type 2 Diabetes: A Community-Based Cohort Study
title_full_unstemmed Menarcheal Age and Risk of Type 2 Diabetes: A Community-Based Cohort Study
title_short Menarcheal Age and Risk of Type 2 Diabetes: A Community-Based Cohort Study
title_sort menarcheal age and risk of type 2 diabetes: a community-based cohort study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5463289/
https://www.ncbi.nlm.nih.gov/pubmed/27840328
http://dx.doi.org/10.4274/jcrpe.3370
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