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The Effectiveness of Cinacalcet as an Adjunctive Therapy for Hereditary 1,25 Dihydroxyvitamin D(3)-Resistant Rickets

High doses of oral calcium or long-term calcium infusions are recommended to correct the hypocalcemia and secondary hyperparathyroidism in patients with hereditary 1,25 dihydroxyvitamin D(3)-resistant rickets (HVDRR). Preliminary studies revealed that calcimimetics may be a safe and effective therap...

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Autores principales: Akıncı, Ayşehan, Dündar, İsmail, Kıvılcım, Meltem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Galenos Publishing 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5463292/
https://www.ncbi.nlm.nih.gov/pubmed/27796266
http://dx.doi.org/10.4274/jcrpe.3486
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author Akıncı, Ayşehan
Dündar, İsmail
Kıvılcım, Meltem
author_facet Akıncı, Ayşehan
Dündar, İsmail
Kıvılcım, Meltem
author_sort Akıncı, Ayşehan
collection PubMed
description High doses of oral calcium or long-term calcium infusions are recommended to correct the hypocalcemia and secondary hyperparathyroidism in patients with hereditary 1,25 dihydroxyvitamin D(3)-resistant rickets (HVDRR). Preliminary studies revealed that calcimimetics may be a safe and effective therapeutic choice in children with secondary hyperparathyroidism. Our aim was to observe the efficacy of cinacalcet in the normalization of secondary hyperparathyroidism and hypophosphatemia in two siblings aged 2.5 years and 6 months with HVDRR who did not respond to traditional treatment regimes. Both patients were admitted to the hospital with severe hypocalcemia. They were treated with high doses of calcitriol and calcium infusions intravenously. Secondary hyperparathyroidism was normalized temporarily, but did not improve completely. Cinacalcet (0.25 mg/kg) once a day along with the high doses of oral calcium and calcitriol was added to the treatment schedule. After 3 months, biochemical and radiologic findings reverted to normal. Our findings indicate that cinacalcet is effective in normalizing the hyperparathyroidism and hypophosphatemia in these cases and in improving the bone pathology.
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spelling pubmed-54632922017-06-15 The Effectiveness of Cinacalcet as an Adjunctive Therapy for Hereditary 1,25 Dihydroxyvitamin D(3)-Resistant Rickets Akıncı, Ayşehan Dündar, İsmail Kıvılcım, Meltem J Clin Res Pediatr Endocrinol Case Report High doses of oral calcium or long-term calcium infusions are recommended to correct the hypocalcemia and secondary hyperparathyroidism in patients with hereditary 1,25 dihydroxyvitamin D(3)-resistant rickets (HVDRR). Preliminary studies revealed that calcimimetics may be a safe and effective therapeutic choice in children with secondary hyperparathyroidism. Our aim was to observe the efficacy of cinacalcet in the normalization of secondary hyperparathyroidism and hypophosphatemia in two siblings aged 2.5 years and 6 months with HVDRR who did not respond to traditional treatment regimes. Both patients were admitted to the hospital with severe hypocalcemia. They were treated with high doses of calcitriol and calcium infusions intravenously. Secondary hyperparathyroidism was normalized temporarily, but did not improve completely. Cinacalcet (0.25 mg/kg) once a day along with the high doses of oral calcium and calcitriol was added to the treatment schedule. After 3 months, biochemical and radiologic findings reverted to normal. Our findings indicate that cinacalcet is effective in normalizing the hyperparathyroidism and hypophosphatemia in these cases and in improving the bone pathology. Galenos Publishing 2017-06 2017-06-01 /pmc/articles/PMC5463292/ /pubmed/27796266 http://dx.doi.org/10.4274/jcrpe.3486 Text en © Journal of Clinical Research in Pediatric Endocrinology, Published by Galenos Publishing. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Akıncı, Ayşehan
Dündar, İsmail
Kıvılcım, Meltem
The Effectiveness of Cinacalcet as an Adjunctive Therapy for Hereditary 1,25 Dihydroxyvitamin D(3)-Resistant Rickets
title The Effectiveness of Cinacalcet as an Adjunctive Therapy for Hereditary 1,25 Dihydroxyvitamin D(3)-Resistant Rickets
title_full The Effectiveness of Cinacalcet as an Adjunctive Therapy for Hereditary 1,25 Dihydroxyvitamin D(3)-Resistant Rickets
title_fullStr The Effectiveness of Cinacalcet as an Adjunctive Therapy for Hereditary 1,25 Dihydroxyvitamin D(3)-Resistant Rickets
title_full_unstemmed The Effectiveness of Cinacalcet as an Adjunctive Therapy for Hereditary 1,25 Dihydroxyvitamin D(3)-Resistant Rickets
title_short The Effectiveness of Cinacalcet as an Adjunctive Therapy for Hereditary 1,25 Dihydroxyvitamin D(3)-Resistant Rickets
title_sort effectiveness of cinacalcet as an adjunctive therapy for hereditary 1,25 dihydroxyvitamin d(3)-resistant rickets
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5463292/
https://www.ncbi.nlm.nih.gov/pubmed/27796266
http://dx.doi.org/10.4274/jcrpe.3486
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