Cargando…

Regulating STING in health and disease

The presence of cytosolic double-stranded DNA molecules can trigger multiple innate immune signalling pathways which converge on the activation of an ER-resident innate immune adaptor named “STimulator of INterferon Genes (STING)”. STING has been found to mediate type I interferon response downstrea...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Yang, Wilson, Heather L., Kiss-Toth, Endre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5463399/
https://www.ncbi.nlm.nih.gov/pubmed/28596706
http://dx.doi.org/10.1186/s12950-017-0159-2
_version_ 1783242701262553088
author Li, Yang
Wilson, Heather L.
Kiss-Toth, Endre
author_facet Li, Yang
Wilson, Heather L.
Kiss-Toth, Endre
author_sort Li, Yang
collection PubMed
description The presence of cytosolic double-stranded DNA molecules can trigger multiple innate immune signalling pathways which converge on the activation of an ER-resident innate immune adaptor named “STimulator of INterferon Genes (STING)”. STING has been found to mediate type I interferon response downstream of cyclic dinucleotides and a number of DNA and RNA inducing signalling pathway. In addition to its physiological function, a rapidly increasing body of literature highlights the role for STING in human disease where variants of the STING proteins, as well as dysregulated STING signalling, have been implicated in a number of inflammatory diseases. This review will summarise the recent structural and functional findings of STING, and discuss how STING research has promoted the development of novel therapeutic approaches and experimental tools to improve treatment of tumour and autoimmune diseases.
format Online
Article
Text
id pubmed-5463399
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-54633992017-06-08 Regulating STING in health and disease Li, Yang Wilson, Heather L. Kiss-Toth, Endre J Inflamm (Lond) Review The presence of cytosolic double-stranded DNA molecules can trigger multiple innate immune signalling pathways which converge on the activation of an ER-resident innate immune adaptor named “STimulator of INterferon Genes (STING)”. STING has been found to mediate type I interferon response downstream of cyclic dinucleotides and a number of DNA and RNA inducing signalling pathway. In addition to its physiological function, a rapidly increasing body of literature highlights the role for STING in human disease where variants of the STING proteins, as well as dysregulated STING signalling, have been implicated in a number of inflammatory diseases. This review will summarise the recent structural and functional findings of STING, and discuss how STING research has promoted the development of novel therapeutic approaches and experimental tools to improve treatment of tumour and autoimmune diseases. BioMed Central 2017-06-07 /pmc/articles/PMC5463399/ /pubmed/28596706 http://dx.doi.org/10.1186/s12950-017-0159-2 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Li, Yang
Wilson, Heather L.
Kiss-Toth, Endre
Regulating STING in health and disease
title Regulating STING in health and disease
title_full Regulating STING in health and disease
title_fullStr Regulating STING in health and disease
title_full_unstemmed Regulating STING in health and disease
title_short Regulating STING in health and disease
title_sort regulating sting in health and disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5463399/
https://www.ncbi.nlm.nih.gov/pubmed/28596706
http://dx.doi.org/10.1186/s12950-017-0159-2
work_keys_str_mv AT liyang regulatingstinginhealthanddisease
AT wilsonheatherl regulatingstinginhealthanddisease
AT kisstothendre regulatingstinginhealthanddisease